Clinical trials for prion disease: difficult challenges, but hope for the future.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.Neurology · 2013
   Trial
2. Creutzfeldt-Jakob Disease Following Kidney Transplantation.Cureus · 2022
   Article
3. The genetic Creutzfeldt-Jakob disease with E200K mutation: analysis of clinical, genetic and laboratory features of 30 Chinese patients.Scientific reports · 2019
   Article
4. In vitro neutralization of prions with PrP(Sc)-specific antibodies.Prion · 2015
   Article
5. Ethics in prion disease.Progress in neurobiology · 2013
   Article
6. Differential diagnosis of Jakob-Creutzfeldt disease.Archives of neurology · 2012
   Article
7. Diagnosis and treatment of rapidly progressive dementias.Neurology. Clinical practice · 2012
   Article
8. Translational research in neurology: dementia.Archives of neurology · 2012
   Review
9. Fatal prion disease in a mouse model of genetic E200K Creutzfeldt-Jakob disease.PLoS pathogens · 2011
   Article
10. Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Neurotoxicity research · 2011
    Article
11. Development of an ultra-rapid diagnostic method based on heart-type fatty acid binding protein levels in the CSF of CJD patients.Cellular and molecular neurobiology · 2010
    Article
12. The importance of recognizing faciobrachial dystonic seizures in rapidly progressive dementias.Dementia & neuropsychologia
    Article
13. Diagnosis and evaluation of a patient with rapidly progressive dementia.Missouri medicine
    Review

Corrections and comments

• Comment on
  Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial.2009

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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