ArticleCurrent opinion in chemical biology2009
Peroxo and oxo intermediates in mononuclear nonheme iron enzymes and related active sites.
Article in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Review
- Impact of Secondary Sphere Hydrogen Bonds on OJournal of the American Chemical Society · 2025Article
- Article
- Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase AspH.Chemphyschem : a European journal of chemical physics and physical chemistry · 2024Article
- The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A.Inorganic chemistry · 2024Article
- Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.Chemical science · 2024Article
- An S=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation.Angewandte Chemie (International ed. in English) · 2023Article
- Formation of cobalt-oxygen intermediates by dioxygen activation at a mononuclear nonheme cobalt(ii) center.Dalton transactions (Cambridge, England : 2003) · 2021Article
- Superoxide Oxidation by a Thiolate-Ligated Iron Complex and Anion Inhibition.Inorganic chemistry · 2021Article
- Structure-Spectroscopy Correlations for Intermediate Q of Soluble Methane Monooxygenase: Insights from QM/MM Calculations.Journal of the American Chemical Society · 2021Article
- How Metal Ion Lewis Acidity and Steric Properties Influence the Barrier to Dioxygen Binding, Peroxo O-O Bond Cleavage, and Reactivity.Journal of the American Chemical Society · 2019Article
- Characterization of the Earliest Intermediate of Fe-NJournal of the American Chemical Society · 2019Article
- Selective C-H halogenation over hydroxylation by non-heme iron(iv)-oxo.Chemical science · 2018Article
- HACS catalysis · 2018Article
- Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes.Angewandte Chemie (International ed. in English) · 2017Article
- O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase.Journal of the American Chemical Society · 2017Article
- Metal-Assisted Oxo Atom Addition to an Fe(III) Thiolate.Journal of the American Chemical Society · 2017Article
- OBiochemistry · 2016Article
- Tuning the Relative Stability and Reactivity of Manganese Dioxygen and Peroxo Intermediates via Systematic Ligand Modification.Accounts of chemical research · 2015Article
- Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species.Journal of the American Chemical Society · 2015Article
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Abstract
Fe(III)OOH and Fe(IV)O intermediates have now been documented in a number of nonheme iron active sites. In this Current Opinion we use spectroscopy combined with electronic structure calculations to define the frontier molecular orbitals (FMOs) of these species and their contributions to reactivity. For the low-spin Fe(III)OOH species in activated bleomycin we show that the reactivity of this nonheme iron intermediate is very different from that of the analogous Compound 0 of cytochrome P450. For Fe(IV)O S=1 model species we experimentally define the electronic structure and its contribution to reactivity, and computationally evaluate how this would change for the Fe(IV)O S=2 intermediates found in nonheme iron enzymes.
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