ReviewStructure (London, England : 1993)2009
Toward structural elucidation of the gamma-secretase complex.
Review in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Proposed Therapeutic Strategy to Combat Alzheimer's Disease by Targeting Beta and Gamma Secretases.Current Alzheimer research · 2025Review
- Metabolic disorder in Alzheimer's disease.Metabolic brain disease · 2021Review
- Levels of amyloid-beta-42 and CSF pressure are directly related in patients with Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.Neurochemical research · 2017Review
- Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.Drug discovery today · 2017Review
- Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.MicrobiologyOpen · 2016Article
- Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.The Yale journal of biology and medicine · 2016Review
- Notch signalling pathway as an oncogenic factor involved in cancer development.Contemporary oncology (Poznan, Poland) · 2016Review
- Calmodulin Binding Proteins and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2015Article
- Structural biology of presenilin 1 complexes.Molecular neurodegeneration · 2014Review
- Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.Aging cell · 2014Article
- γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.The Journal of biological chemistry · 2014Article
- Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.Biochemistry · 2013Article
- Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis.Molecular neurobiology · 2012Review
- AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.BMC systems biology · 2012Article
- Development of clickable active site-directed photoaffinity probes for γ-secretase.Bioorganic & medicinal chemistry letters · 2012Article
- Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer's disease (AD).Expert opinion on emerging drugs · 2012Article
- An overview of notch signaling in adult tissue renewal and maintenance.Current Alzheimer research · 2012Review
- Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Gamma-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid beta-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the identification and characterization of the membrane complex and its biological functions. One major challenge now is to illuminate the structure of this fascinating and important protease at atomic resolution. Here, we review recent progress on biochemical and biophysical probing of the structure of the four-component complex and discuss obstacles and potential pathways toward elucidating its detailed structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.