ArticleCancer causes & control : CCC2009
Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study.
Article in Cancer causes & control : CCC, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose-Response Meta-Analysis of Prospective Studies.Nutrients · 2022Pooled it
- Consumption of artificially sweetened soft drinks and risk of gastrointestinal cancer: a meta-analysis of observational studies.Public health nutrition · 2021Pooled it
- Intake of artificial sweeteners among adults is associated with reduced odds of gastrointestinal luminal cancers: a meta-analysis of cohort and case-control studies.Nutrition research (New York, N.Y.) · 2021Pooled it
- Consumption of Sweet Beverages and Cancer Risk. A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2021Pooled it
- Dietary patterns and risk of pancreatic cancer: a systematic review.Nutrition reviews · 2017Pooled it
- Concentrated sugars and incidence of prostate cancer in a prospective cohort.The British journal of nutrition · 2018Trial
- An integrative multi-omics analysis reveals a multi-analyte signature of pancreatic ductal adenocarcinoma in serum.Journal of gastroenterology · 2025Article
- Article
- Assessment of Aspartame (E951) Occurrence in Selected Foods and Beverages on the German Market 2000-2022.Foods (Basel, Switzerland) · 2023Article
- Sugar Sweetened and Artificially Sweetened Beverage Consumption and Pancreatic Cancer: A Retrospective Study.Nutrients · 2023Article
- "Sugar-Sweetened Beverages" Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years.Frontiers in oncology · 2022Article
- Consumption of sugar-sweetened beverages and fruit juice and human cancer: a systematic review and dose-response meta-analysis of observational studies.Journal of Cancer · 2021Article
- Health outcomes of non-nutritive sweeteners: analysis of the research landscape.Nutrition journal · 2017Article
- Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case-Control Consortium (PanC4).Annals of oncology : official journal of the European Society for Medical Oncology · 2017Article
- Association of sugary beverages with survival among patients with cancers of the upper aerodigestive tract.Cancer causes & control : CCC · 2016Article
- Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight.Nutrients · 2014Review
- Duration of diabetes and pancreatic cancer in a case-control study in the Midwest and the Iowa Women's Health Study (IWHS) cohort.JOP : Journal of the pancreas · 2013Article
- Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).Annals of oncology : official journal of the European Society for Medical Oncology · 2012Article
- Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk: a pooled analysis of 14 cohort studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).Annals of oncology : official journal of the European Society for Medical Oncology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe examined the associations between sweets, sweetened and unsweetened beverages, and sugars and pancreatic cancer risk.
methodsWe conducted a population-based case-control study (532 cases, 1,701 controls) and used multivariate logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI). Because associations were often different by sex, we present results for men and women combined and separately.
resultsAmong men, greater intakes of total and specific sweets were associated with pancreatic cancer risk (total sweets: OR = 1.9, 95% CI: 1.0, 3.6; sweet condiments: OR = 1.9, 95% CI: 1.2, 3.1; chocolate candy: OR = 2.4, 95% CI: 1.1, 5.0; other mixed candy bars: OR = 3.3, 95% CI: 1.5, 7.3 for 1 + servings/day versus none/rarely). Sweets were not consistently associated with risk among women. Sweetened beverages were not associated with increased pancreatic cancer risk. In contrast, low-calorie soft drinks were associated with increased risk among men only; while other low-/non-caloric beverages (e.g., coffee, tea, and water) were unassociated with risk. Of the three sugars assessed (lactose, fructose, and sucrose), only the milk sugar lactose was associated with pancreatic cancer risk (OR = 2.0, 95% CI: 1.5, 2.7 comparing extreme quartiles).
conclusionThese results provide limited support for the hypothesis that sweets or sugars increase pancreatic cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.