ArticleJournal of the Association for Research in Otolaryngology : JARO2009
Immunocytochemical traits of type IV fibrocytes and their possible relations to cochlear function and pathology.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal.Scientific reports · 2023Article
- TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.Nature communications · 2022Article
- Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022Review
- Age-Related Inflammation and Oxidative Stress in the Cochlea Are Exacerbated by Long-Term, Short-Duration Noise Stimulation.Frontiers in aging neuroscience · 2022Article
- Cochlin Deficiency Protects Aged Mice from Noise-Induced Hearing Loss.International journal of molecular sciences · 2021Article
- Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss.Neuroscience · 2020Article
- On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament.Frontiers in neurology · 2020Review
- Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss.International journal of molecular sciences · 2019Article
- Forgotten Fibrocytes: A Neglected, Supporting Cell Type of the Cochlea With the Potential to be an Alternative Therapeutic Target in Hearing Loss.Frontiers in cellular neuroscience · 2019Article
- Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients.Journal of audiology & otology · 2018Article
- QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A.Journal of negative results in biomedicine · 2016Article
- Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea.Scientific reports · 2016Article
- Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015Article
- Immunohistochemical localization of α2-adrenergic receptors in the neonatal rat cochlea and the vestibular labyrinth.Journal of molecular neuroscience : MN · 2013Article
- Effects of repeated "benign" noise exposures in young CBA mice: shedding light on age-related hearing loss.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Physiopathology of the cochlear microcirculation.Hearing research · 2011Review
- Subcellular distribution and relative expression of fibrocyte markers in the CD/1 mouse cochlea assessed by semiquantitative immunogold electron microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
One of the more consistent and least understood changes in the aging human cochlea is the progressive loss of fibrocytes within the spiral ligament. This report presents an animal model for type IV fibrocyte loss, along with immunocytochemical evidence that noise-induced loss of these cells may account for previously unexplained hearing losses. The remarkably low threshold for noise-induced loss of type IV fibrocytes, approximately 24 dB less than the threshold for adjacent hair cell destruction, may account for the prevalence of missing fibrocytes in humans. In mice, changes in the spectrum of traumatizing noise had little effect upon the site of loss of the fibrocytes, suggesting that the primary site of damage that induced the loss was the basal-most cochlear turn, a site expected to be damaged by all three noise bands. Type IV fibrocytes were found to immunostain for connective tissue growth factor (CTGF) and for transforming growth factor beta receptor 3, a receptor that is known to activate CTGF expression. Type IV fibrocytes lack immunostaining for adenosine triphosphatase and connexins that are key players in potassium ion uptake and transmission, which suggests that they play little, if any, role in potassium recycling from perilymphatic space to the endolymphatic space. Consequently, their loss probably does not directly reduce this process. Immunostaining for a receptor for CTGF, low-density-lipoprotein-related protein 1, indicated that CTGF acts as an autocrine and a paracrine agent within the cochlea. The lack of CTGF paracrine effects following noise-induced loss of type IV fibrocytes may account for previously unexplained hearing losses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.