ArticleJournal of cancer research and clinical oncology2009
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
Article in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Development and validation of a DYX1C1- and GNAI1-based nomogram for predicting relapse in HER2-positive breast cancer treated with trastuzumab.Translational cancer research · 2026Article
- Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2.BMC molecular and cell biology · 2023Article
- The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization.Biomolecules · 2022Review
- Human Hsp90 cochaperones: perspectives on tissue-specific expression and identification of cochaperones with similar in vivo functions.Cell stress & chaperones · 2021Review
- Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly.International journal of molecular sciences · 2019Review
- Primary Ciliary Dyskinesia (PCD): A genetic disorder of motile cilia.Translational science of rare diseases · 2019Article
- Establishment of the early cilia preassembly protein complex during motile ciliogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3.Nature communications · 2017Article
- DYX1C1 is required for axonemal dynein assembly and ciliary motility.Nature genetics · 2013Article
- The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function.PloS one · 2013Article
- The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.Molecular endocrinology (Baltimore, Md.) · 2012Article
- The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.BMC cancer · 2012Article
- Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children.Behavioral and brain functions : BBF · 2011Article
- A theoretical molecular network for dyslexia: integrating available genetic findings.Molecular psychiatry · 2011Review
- Genetic factors contributing to human primary ciliary dyskinesia and male infertility.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWith three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In this study, we attempted to identify the potential interaction of DYX1C1 and heat shock protein, and the role of DYX1C1 in breast cancer. MAIN
methodsGST pull-down, a yeast two-hybrid system, RT-PCR, site-directed mutagenesis approach. KEY
findingsOur study initially confirmed DYX1C1, a dyslexia related protein, could interact with Hsp70 and Hsp90 via GST pull-down and a yeast two-hybrid system. And we verified that EEVD, the C-terminal residues of DYX1C1, is responsible for the identified association. Further, DYX1C1 mRNA was significantly overexpressed in malignant breast tumor, linking with the up-regulated expression of Hsp70 and Hsp90. SIGNIFICANCE: These results suggest that DYX1C1 is a novel Hsp70 and Hsp90-interacting co-chaperone protein and its expression is associated with malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.