ArticleCurrent genetics2009
A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa.
Article in Current genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 28 citations in OpenAlex.
- Genetic Characteristics and Metabolic Interactions betweenPlants (Basel, Switzerland) · 2022Review
- Sordaria macrospora: 25 years as a model organism for studying the molecular mechanisms of fruiting body development.Applied microbiology and biotechnology · 2020Review
- A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis.PloS one · 2019Article
- Functional Analysis of Developmentally Regulated Genes chs7 and sec22 in the Ascomycete Sordaria macrospora.G3 (Bethesda, Md.) · 2015Article
- Article
- The polyketide synthase gene pks4 of Trichoderma reesei provides pigmentation and stress resistance.Eukaryotic cell · 2013Article
- Deletion and gene expression analyses define the paxilline biosynthetic gene cluster in Penicillium paxilli.Toxins · 2013Article
- Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans.Applied and environmental microbiology · 2012Article
- Analyses of expressed sequence tags in Neurospora reveal rapid evolution of genes associated with the early stages of sexual reproduction in fungi.BMC evolutionary biology · 2012Article
- Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development.BMC genomics · 2012Article
- ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans.Eukaryotic cell · 2010Article
- De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis.PLoS genetics · 2010Article
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1 author at 1 institution in 1 country.
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Abstract
During fungal fruiting body development, hyphae aggregate to form multicellular structures that protect and disperse the sexual spores. Analysis of microarray data revealed a gene cluster strongly upregulated during fruiting body development in the ascomycete Sordaria macrospora. Real time PCR analysis showed that the genes from the orthologous cluster in Neurospora crassa are also upregulated during development. The cluster encodes putative polyketide biosynthesis enzymes, including a reducing polyketide synthase. Analysis of knockout strains of a predicted dehydrogenase gene from the cluster showed that mutants in N. crassa and S. macrospora are delayed in fruiting body formation. In addition to the upregulated cluster, the N. crassa genome comprises another cluster containing a polyketide synthase gene, and five additional reducing polyketide synthase (rpks) genes that are not part of clusters. To study the role of these genes in sexual development, expression of the predicted rpks genes in S. macrospora (five genes) and N. crassa (six genes) was analyzed; all but one are upregulated during sexual development. Analysis of knockout strains for the N. crassa rpks genes showed that one of them is essential for fruiting body formation. These data indicate that polyketides produced by RPKSs are involved in sexual development in filamentous ascomycetes.
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