ReviewPsychopharmacology2009
Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia.
Review in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies.Psychological medicine · 2013Pooled it
- Increased Striatal Presynaptic Dopamine in a Nonhuman Primate Model of Maternal Immune Activation: A Longitudinal Neurodevelopmental Positron Emission Tomography Study With Implications for Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Microglia sequelae: brain signature of innate immunity in schizophrenia.Translational psychiatry · 2022Review
- Lack of Vesicular Zinc Does Not Affect the Behavioral Phenotype of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation Mice.Frontiers in behavioral neuroscience · 2022Article
- The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders.Brain and behavior · 2019Review
- Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation.Translational psychiatry · 2019Article
- Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations.Schizophrenia bulletin · 2018Review
- Alteration of adaptive behaviors of progeny after maternal mobile phone exposure.Environmental science and pollution research international · 2018Article
- Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [The American journal of psychiatry · 2017Article
- Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations.Brain sciences · 2016Review
- Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology?Schizophrenia research · 2016Review
- From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways.Molecular psychiatry · 2016Review
- Cerebral Response to Peripheral Challenge with a Viral Mimetic.Neurochemical research · 2016Review
- The role of inflammation in schizophrenia.Frontiers in neuroscience · 2015Review
- Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis.Neuroscience · 2014Review
- Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring.The American journal of psychiatry · 2014Article
- Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring.Biological psychiatry · 2014Article
- N-Acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats.Metabolic brain disease · 2013Article
- A conceptual and practical guide to the behavioural evaluation of animal models of the symptomatology and therapy of schizophrenia.Cell and tissue research · 2013Review
- Evidence for a dysregulated immune system in the etiology of psychiatric disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePrenatal exposure to infection is a notable environmental risk factor in the development of schizophrenia. One prevalent hypothesis suggests that infection-induced disruption of early prenatal brain development predisposes the organism to long-lasting structural and functional brain abnormalities. Many of the prenatal infection-induced functional brain abnormalities appear to be closely associated with imbalances in the mesocorticolimbic dopamine system in adult life, suggesting that disruption of functional and structural dopaminergic development may be at the core of the developmental neuropathology associated with psychosis-related abnormalities induced by prenatal exposure to infection.
objectivesIn this review, we integrate recent findings derived from experimental models in animals with parallel research in humans which supports this hypothesis. We thereby highlight the developmental perspective of abnormal DA functions following in-utero exposure to infection in relation to the developmental and maturational mechanisms potentially involved in schizophrenia.
resultsExperimental investigations show that early prenatal immune challenge can lead to the emergence of early structural and functional alterations in the mesocorticolimbic DA system, long before the onset of the full spectrum of psychosis-associated behavioral and cognitive abnormalities in adulthood.
conclusionsDopaminergic mal-development in general, and following prenatal immune activation in particular, may represent a primary etiopathological mechanism in the development of schizophrenia and related disorders. This hypothesis differs from the view that dopaminergic abnormalities in schizophrenia may be secondary to abnormalities in other brain structures and/or neurotransmitter systems. The existence of primary dopaminergic mechanisms may have important implications for the identification and early treatment of individuals prodromally symptomatic for schizophrenia.
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