ArticleBritish journal of cancer2009
Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.
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Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The risk for subsequent primary lung cancer after cervical carcinoma: A quantitative analysis based on 864,627 cases.PloS one · 2024Pooled it
- A meta-analysis of the association between adolescent pregnancy and the risk of gynecological cancers.Epidemiology and health · 2024Pooled it
- Knowledge, attitudes, and practices of cervical Cancer screening among HIV-positive and HIV-negative women participating in human papillomavirus screening in rural Zimbabwe.BMC women's health · 2020Trial
- Two target cells for HPV infection at the cervix?Virus research · 2026Review
- Cancer pattern in Bhutan (2014-2022): Findings from population-based cancer registry-A pathway to monitor cancer control activities.International journal of cancer · 2026Article
- Cancer: a looming public health crisis in Africa-a call to accelerate equitable access to medicines.The oncologist · 2026Article
- Age at first marriage, menopause status and cervical cancer risk in a middle eastern country: a national cancer registry-based case-control study.Cancer causes & control : CCC · 2026Article
- Human Papillomavirus (HPV) and Infertility: A Cross-Sectional Study Exploring Its Prevalence and Effects in Iranian Couples.Health science reports · 2025Article
- Human papillomavirus (HPV) infection and liquid-based cytologic tests among cervical screening participants in Shannan City, Tibet, China, during 2021-2022.BMC infectious diseases · 2025Article
- Risk of Cervical Carcinoma After Unfavorable Behavior and High Genetic Risk in the UK Biobank: A Prospective Nested Case-Control Study.Biomedicines · 2025Article
- Dual opposing effects of TBBPS/TCBPA on cervical cell proliferation: suppression in normal cells versus promotion in cancer via the cGAS-STING pathway.American journal of cancer research · 2025Article
- Individual-level determinants of late-stage cervical cancer diagnosis and their implications for prevention and control.Ecancermedicalscience · 2025Article
- Investigating the Mediating Role of Mental Disorders in the Relationship Between Early Sexual Intercourse and Intentional Self-Harm: A Two-Step and Multivariable Mendelian Randomization Study.Brain and behavior · 2024Article
- Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination.Nature reviews. Clinical oncology · 2024Review
- The level of medical students' knowledge regarding the prevention of cervical cancer.Annals of medicine and surgery (2012) · 2024Article
- Assessment of HPV Knowledge and Awareness among Students and Staff at IBB University, Niger State, Nigeria: Implications for Health Education and Prevention.Healthcare (Basel, Switzerland) · 2024Article
- Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in setting of Addis Ababa, Ethiopia.Scientific reports · 2024Article
- Causal effect of age first had sexual intercourse and lifetime number of sexual partners on cervical cancer.Heliyon · 2024Article
- Association between oral contraceptives and cervical cancer: A retrospective case-control study based on the National Health and Nutrition Examination Survey.Frontiers in pharmacology · 2024Article
- Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology.SAGE open medicine · 2024Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early age at first sexual intercourse (AFSI) has long been associated with an increased risk of invasive cervical carcinoma (ICC). Age at first pregnancy (AFP) and ICC have been investigated less, although AFSI and AFP are strongly interrelated in most developing countries. A pooled analysis of case-control studies on ICC from eight developing countries with 1864 cases and 1719 controls investigated the roles of AFSI, AFP, and ICC risk. Age at first sexual intercourse, AFP and age at first marriage (AFM) were highly interrelated and had similar ICC risk estimates. Compared with women with AFSI > or = 21 years, the odds ratio (OR) of ICC was 1.80 (95% CI: 1.50-2.39) among women with AFSI 17-20 years and 2.31 (95% CI: 1.85-2.87) for AFSI < or = 16 years (P-trend <0.001). No statistical interaction was detected between AFSI and any established risk factors for ICC. The ICC risk was 2.4-fold among those who reported AFSI and AFP at < or = 16 years compared with those with AFSI and AFP at > or = 21 years. These data confirm AFSI and AFB as risk factors for ICC in eight developing countries, but any independent effects of these two events could not be distinguished.
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