ReviewJournal of Alzheimer's disease : JAD2009
A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.
Review in Journal of Alzheimer's disease : JAD, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer's disease created by integrative analysis of multi-omics data.Alzheimer's research & therapy · 2020Pooled it
- Genome-wide association study identifies loci affecting blood copper, selenium and zinc.Human molecular genetics · 2013Pooled it
- A Review on the Pathophysiology of Alzheimer's Disease.Current protein & peptide science · 2026Review
- What Are the Functions of Zinc in the Nervous System?Neurology · 2023Article
- Distribution of Iron, Copper, Zinc and Cadmium in Glia, Their Influence on Glial Cells and Relationship with Neurodegenerative Diseases.Brain sciences · 2023Review
- Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension.Cell cycle (Georgetown, Tex.) · 2023Article
- The Important Role of Zinc in Neurological Diseases.Biomolecules · 2022Review
- Identification of potential blood biomarkers for early diagnosis of Alzheimer's disease through immune landscape analysis.npj aging · 2022Article
- Microglia and Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Iron in Alzheimer's Disease: From Physiology to Disease Disabilities.Biomolecules · 2022Review
- Zinc in Regulating Protein Kinases and Phosphatases in Neurodegenerative Diseases.Biomolecules · 2022Review
- The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction.Biomedicines · 2021Review
- Zinc in the Brain: Friend or Foe?International journal of molecular sciences · 2020Review
- Zinc Therapy in Early Alzheimer's Disease: Safety and Potential Therapeutic Efficacy.Biomolecules · 2020Review
- Quantum chemical molecular dynamics and metadynamics simulation of aluminium binding to amyloid-β and related peptides.Royal Society open science · 2020Article
- Article
- Zinc: A Necessary Ion for Mammalian Sperm Fertilization Competency.International journal of molecular sciences · 2018Review
- Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Efficacy and Pharmacological Mechanism of ZnScientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although multiple studies have suggested a role for alterations of zinc (Zn) and zinc transport (ZnT) proteins in the pathogenesis of Alzheimer's disease, the exact role of this essential trace element in the progression of the disease remains unclear. The following review discusses the normal role of Zn and ZnT proteins in brain and the potential effects of their alteration in the pathogenesis of Alzheimer's disease, particularly in the processing of the amyloid-beta protein precursor and amyloid-beta peptide generation and aggregation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.