Evidence map›Paper›PMID 19276266›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009

Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.

Vaqar Mustafa Adhami, Imtiaz Ahmad Siddiqui, Sami Sarfaraz, Sabih Islam Khwaja, Bilal Bin Hafeez, Nihal Ahmad, Hasan Mukhtar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vaqar Mustafa AdhamiDepartment of Dermatology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Imtiaz Ahmad Siddiqui
Sami Sarfaraz
Sabih Islam Khwaja
Bilal Bin Hafeez
Nihal Ahmad
Hasan Mukhtar
University of Wisconsin–Madison · US

Funding

The Role of JunD in Androgen-Induced Changes in Prostate Gland Redox StateP50DK065303 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BUSHMAN, WADE A. · 2003 to 2007
$4.0M
Green Tea in Chemoprevention of Prostate CancerR01CA078809 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MUKHTAR, HASAN · 1999 to 2008
$1.9M
Molecular Targets for Prevention of Prostate Cancer by Green TeaR01CA101039 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MUKHTAR, HASAN · 2003 to 2007
$1.6M
Pomegranate for Chemoprevention and Chemotherapy of Prostate CancerR01CA120451 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MUKHTAR, HASAN · 2007 to 2011
$1.4M
NCI NIH HHS R01 CA078809NCI NIH HHS R01 CA101039NCI NIH HHS R01 CA120451NCI NIH HHS R01 CA 78809NIDDK NIH HHS P50 DK065303NIDDK NIH HHS P50 DK065303-01
6 · The paper itself

Abstract

purposeWe have shown previously that oral feeding of green tea polyphenols (GTP) to transgenic adenocarcinoma of the mouse prostate mice in a purely chemopreventive setting significantly inhibits prostate cancer development. To translate this to a human situation, the present study was designed to identify the stage of prostate cancer that is most vulnerable to chemopreventive intervention by GTP. EXPERIMENTAL

designGTP infusion (0.1% in drinking water) to transgenic adenocarcinoma of the mouse prostate was initiated at ages representing different stage of the disease: (a) 6 weeks (group 1, normal prostate), (b) 12 weeks (group 2, prostatic intraepithelial neoplasia), (c) 18 weeks (group 3, well-differentiated adenocarcinoma), and (b) 28 weeks (group 4, moderately differentiated adenocarcinoma). At age 32 weeks, subsets of animals were evaluated by magnetic resonance imaging, ultrasound, and prostate weight and for serum insulin-like growth factor (IGF)-I/IGF binding protein-3 and IGF signaling.

resultsTumor-free survival was extended to 38 weeks (P < 0.001) in group 1, 31 weeks (P < 0.01) in group 2, and 24 weeks (P < 0.05) in group 3 compared with 19 weeks in water-fed controls. Median life expectancy was 68 weeks in group 1, 63 weeks in group 2, 56 weeks in group 3, and 51 weeks in group 4 compared with 42 weeks in the control mice. IGF-I and its downstream targets including phosphatidylinositol 3-kinase, pAkt, and phosphorylated extracellular signal-regulated kinase were significantly inhibited only when intervention was initiated early when prostatic intraepithelial neoplasia lesions were common.

conclusionsOur studies indicate that chemopreventive potential of GTP decreases with advancing stage of the disease and underscore the need to design appropriate chemoprevention clinical trails.

Indexed as

TeaAdenocarcinomaAnimalsAnticarcinogenic AgentsDisease Models, AnimalFemaleFlavonoidsInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLNeoplasm StagingPhenolsPolyphenolsAnticarcinogenic AgentsFlavonoidsInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IPhenolsPolyphenolsTea

Identifiers

PMID19276266
PMCPMC2991083
OpenAlexW2168740776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.