ArticleThe Journal of clinical endocrinology and metabolism2009
Glucoregulatory physiology in subjects with low-normal, high-normal, or impaired fasting glucose.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Pathobiology of Prediabetes: Understanding and Interrupting Progressive Dysglycemia and Associated Complications.Diabetes · 2025Review
- Associations of fluctuations in blood glucose and insulin with hypoglycemic symptoms.Scientific reports · 2025Article
- Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia.BMJ open diabetes research & care · 2024Article
- Association between high sensitivity cardiac troponin and mortality risk in the non-diabetic population: findings from the National Health and Nutrition Examination Survey.Cardiovascular diabetology · 2023Article
- Association between serum gamma glutamyl transferase and fasting blood glucose in Chinese people: A 6-year follow-up study.Journal of diabetes investigation · 2023Article
- DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases.Journal of diabetes and its complications · 2022Review
- A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups.Nutrients · 2021Review
- Article
- Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes.International journal of endocrinology · 2021Article
- Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction.Endocrinology and metabolism clinics of North America · 2018Review
- Risk Score for Detecting Dysglycemia: A Cross-Sectional Study of a Working-Age Population in an Oil Field in China.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Insulin-sensitive and insulin-resistant obese and non-obese phenotypes: role in prediction of incident pre-diabetes in a longitudinal biracial cohort.BMJ open diabetes research & care · 2017Article
- Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications.Experimental biology and medicine (Maywood, N.J.) · 2016 · on this mapReview
- Glucoregulatory function among African Americans and European Americans with normal or pre-diabetic hemoglobin A1c levels.Metabolism: clinical and experimental · 2014Article
- Linking pre-diabetes with benign prostate hyperplasia. IGFBP-3: a conductor of benign prostate hyperplasia development orchestra?PloS one · 2013Article
- Metabolomic prediction of diabetes and cardiovascular risk.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2012Article
- Normal fasting plasma glucose and risk of type 2 diabetes.Diabetes care · 2011Article
- Prediabetes as a therapeutic target.Clinical chemistry · 2011Review
- Fasting plasma leptin level is a surrogate measure of insulin sensitivity.The Journal of clinical endocrinology and metabolism · 2010Article
- High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation.Diabetologia · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe determined whether variations in fasting plasma glucose (FPG) within the nondiabetic range represent differences in insulin action or secretion. SUBJECTS AND
methodsUsing results of the 75-g oral glucose tolerance test, we classified 39 adults (body mass index range 20-56 kg/m2) as having normal fasting glucose (NFG, <100 mg/dl, n = 24) or impaired fasting glucose (IFG, 100-125 mg/dl, n = 15). The NFG group was subdivided into low-NFG (<90 mg/dl, n = 11) and high-NFG (90-99 mg/dl, n = 13). The 2-h oral glucose tolerance test plasma glucose value was used to assign normal or impaired glucose tolerance (IGT) status. Insulin sensitivity was assessed by hyperinsulinemic euglycemic clamp, quantitative insulin sensitivity check index, and homeostasis model assessment of insulin resistance; beta-cell function was assessed by calculating the insulinogenic index, homeostasis model assessment, and the disposition index.
resultsCompared with low-NFG subjects, insulin sensitivity and glucose tolerance were lower among persons with isolated IFG and combined IFG-IGT. The hyperinsulinemic euglycemic clamp (micromol/kg x min(-1)/pmol/liter) was 0.109 +/- 0.011 in low-NFG subjects, 0.088 +/- 0.009 in IFG subjects (P = 0.04), and 0.022 +/- 0.003 in IFG-IGT subjects (P = 0.0014). The spread in FPG from 70-125 mg/dl was associated with a greater than 3-fold difference in insulin sensitivity. Compared with low-NFG subjects, the disposition index decreased by 32.8% in high-NFG subjects (P = 0.08), by 45.6% in subjects with isolated IFG (P < 0.02), and by 49.8% (P < 0.02) in those with combined IFG-IGT.
conclusionCompared with persons with low-NFG, those with IFG or combined IFG-IGT have significant alteration of glucoregulatory physiology, whereas high-NFG (pre-prediabetes) status might portend nascent glucoregulatory perturbations.
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