ArticleProceedings of the National Academy of Sciences of the United States of America2009
The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spontaneous recovery from amblyopia following fellow eye vision loss: a systematic review and narrative synthesis.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2024Pooled it
- Article
- The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.Annual review of neuroscience · 2026Review
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex.Neuroscience bulletin · 2025Review
- Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Anatomical and molecular development of the human primary visual cortex.Frontiers in cellular neuroscience · 2024Review
- Review
- Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Metaplasticity: a key to visual recovery from amblyopia in adulthood?Current opinion in ophthalmology · 2022Review
- GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour.Behavioural brain research · 2022Article
- The mechanism of enriched environment repairing the learning and memory impairment in offspring of prenatal stress by regulating the expression of activity-regulated cytoskeletal-associated and insulin-like growth factor-2 in hippocampus.Environmental health and preventive medicine · 2021Article
- A Practical Guide to SparseFrontiers in neuroscience · 2021Article
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Rethinking amblyopia 2020.Vision research · 2020Review
- Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- A Primer on Constructing Plasticity Phenotypes to Classify Experience-Dependent Development of the Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons.Oxidative medicine and cellular longevity · 2020Article
- Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex.Frontiers in cellular neuroscience · 2020Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Bidirectional synaptic plasticity during development ensures that appropriate synapses in the brain are strengthened and maintained while inappropriate connections are weakened and eliminated. This plasticity is well illustrated in mouse visual cortex, where monocular deprivation during early postnatal development leads to a rapid depression of inputs from the deprived eye and a delayed strengthening of inputs from the non-deprived eye. The mechanisms that control these bidirectional synaptic modifications remain controversial. Here we demonstrate, both in vitro and in vivo, that genetic deletion or reduction of the NR2A NMDA receptor subunit impairs activity-dependent weakening of synapses and enhances the strengthening of synapses. Although brief monocular deprivation in juvenile WT mice normally causes a profound depression of the deprived-eye response without a change in the non-deprived eye response, NR2A-knockout mice fail to exhibit deprivation-induced depression and instead exhibit precocious potentiation of the non-deprived eye inputs. These data support the hypothesis that a reduction in the NR2A/B ratio during monocular deprivation is permissive for the compensatory potentiation of non-deprived inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.