ArticleThe Journal of biological chemistry2009
Dendritic assembly of heteromeric gamma-aminobutyric acid type B receptor subunits in hippocampal neurons.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2.Journal of cell science · 2022Article
- A magnetic affinity approach to identify plant GABA-binding proteins.Turkish journal of biology = Turk biyoloji dergisi · 2019Article
- CaNature communications · 2017Article
- Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes.American journal of human genetics · 2017Article
- ALS-linked protein disulfide isomerase variants cause motor dysfunction.The EMBO journal · 2016Article
- Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory.Cell research · 2015Article
- Diversifying the secretory routes in neurons.Frontiers in neuroscience · 2015Review
- Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors.Journal of cell science · 2014Article
- Differential regulation of GABAB receptor trafficking by different modes of N-methyl-D-aspartate (NMDA) receptor signaling.The Journal of biological chemistry · 2014Article
- Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.Molecular brain · 2013Article
- A noncanonical postsynaptic transport route for a GPCR belonging to the serotonin receptor family.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation.World journal of biological chemistry · 2012Article
- TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila.PloS one · 2012Article
- Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors.PloS one · 2012Article
- The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The Sushi domains of GABAB receptors function as axonal targeting signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the mechanisms that control synaptic efficacy through the availability of neurotransmitter receptors depends on uncovering their specific intracellular trafficking routes. gamma-Aminobutyric acid type B (GABA(B)) receptors (GABA(B)Rs) are obligatory heteromers present at dendritic excitatory and inhibitory postsynaptic sites. It is unknown whether synthesis and assembly of GABA(B)Rs occur in the somatic endoplasmic reticulum (ER) followed by vesicular transport to dendrites or whether somatic synthesis is followed by independent transport of the subunits for assembly and ER export throughout the somatodendritic compartment. To discriminate between these possibilities we studied the association of GABA(B)R subunits in dendrites of hippocampal neurons combining live fluorescence microscopy, biochemistry, quantitative colocalization, and bimolecular fluorescent complementation. We demonstrate that GABA(B)R subunits are segregated and differentially mobile in dendritic intracellular compartments and that a high proportion of non-associated intracellular subunits exist in the brain. Assembled heteromers are preferentially located at the plasma membrane, but blockade of ER exit results in their intracellular accumulation in the cell body and dendrites. We propose that GABA(B)R subunits assemble in the ER and are exported from the ER throughout the neuron prior to insertion at the plasma membrane. Our results are consistent with a bulk flow of segregated subunits through the ER and rule out a post-Golgi vesicular transport of preassembled GABA(B)Rs.
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