ArticleBiochemical and biophysical research communications2009
NF-kappaB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter.
Article in Biochemical and biophysical research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- ComprehensiveOncology reports · 2025Review
- MMP3 at the crossroads: Linking molecular pathways to disease diagnosis and therapy.Pharmacological research · 2025Review
- Article
- Interleukin-1β triggers matrix metalloprotease-3 expression through p65/RelA activation in melanoma cells.PloS one · 2022Article
- CCL5/CCR5 axis in human diseases and related treatments.Genes & diseases · 2022Review
- Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression.Scientific reports · 2017Article
- Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.American journal of respiratory cell and molecular biology · 2017Article
- ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1.Journal of translational medicine · 2015Article
- The inhibitor of kappa B kinase-epsilon regulates MMP-3 expression levels and can promote lung metastasis.Oncogenesis · 2014Article
- IL-4 inhibition of IL-1 induced Matrix metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal kinase (JNK).Experimental cell research · 2013Article
- The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion.Radiation oncology (London, England) · 2013Article
- Functional gene polymorphism of matrix metalloproteinase-1 is associated with benign hyperplasia of myo- and endometrium in the Russian population.Genetic testing and molecular biomarkers · 2012Article
- A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP.British journal of pharmacology · 2012Article
- miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.The Journal of biological chemistry · 2011Article
- Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by inflammatory cytokines.Pathology and laboratory medicine international · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A 5T/6T polymorphism in the human MMP-3 promoter affects gene expression and impacts the risk and/or severity of various pathological conditions. Chromatin immunoprecipitation (ChIP) in human fibroblasts homozygous for the 6T site demonstrate that it is bound by NF-kappaB and ZBP-89 transcription factors in its native chromatin. ChIP in COS-1 cells transfected with plasmids containing the 5T and 6T sites in the context of 2kb of the MMP-3 promoter showed that NF-kappaB p50 binds preferentially to the 6T site, while more ZBP-89 binding is detected to the 5T site. Over-expressed ZBP-89 increased transcription from the 5T promoter but not from the 6T, while NF-kappaB decreased transcription from both promoters, even in the presence of excess ZBP-89. A model is suggested in which the physiological impact of the polymorphism is dependent on the relative levels and activities of these competing factors in various cell types and conditions.
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