ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2009
Direct and decarboxylation-dependent effects of neurotransmitter precursors on firing of isolated monoaminergic neurons.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the MolluskFrontiers in physiology · 2020Article
- Storage and erasure of behavioural experiences at the single neuron level.Scientific reports · 2019Article
- Increase in serotonin precursor levels reinstates the context memory during reconsolidation.Invertebrate neuroscience : IN · 2019Article
- Comparison of brain monoamine content in three populations ofBiophysics and physicobiology · 2018Article
- Light-dark decision making in snails: Do preceding light conditions matter?Communicative & integrative biology · 2017Article
- Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea.Biology open · 2016Article
- The activity of isolated snail neurons controlling locomotion is affected by glucose.Biophysics (Nagoya-shi, Japan) · 2015Article
- Serotonin precursor (5-hydroxytryptophan) causes substantial changes in the fighting behavior of male crickets, Gryllus bimaculatus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Neural control of olfaction and tentacle movements by serotonin and dopamine in terrestrial snail.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- The neuronal control of cardiac functions in Molluscs.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2011Review
- Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.International journal of Alzheimer's disease · 2010Article
- Coordination of rhythm-generating units via NO and extrasynaptic neurotransmitter release.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate mechanisms that underlie the profound physiological effects of the monoamine precursors 5-hydroxy-L-tryptophan (5-HTP) and L-3,4-dihydroxyphenylalanine (L-DOPA), we examined their action on single monoaminergic neurons isolated from the ganglia of the gastropod snail Lymnaea stagnalis. In isolated serotonergic PeA motoneurons, 5-HTP produced excitation. The effect was mimicked by serotonin at 0.5-1 microM, masked by pretreatment with serotonin at higher concentrations, and abolished by the inhibitor of aromatic amino acid decarboxylase (AAAD) m-hydroxybenzylhydrazine (NSD-1015), the inhibitor of the vesicular monoamine transporter reserpine or the serotonin receptor antagonist mianserin. Exposure of the dopaminergic interneurons RPeD1 to L-DOPA caused a biphasic effect composed of a depolarization followed by a hyperpolarization. AAAD inactivation with NSD-1015, as well as the blockade of dopamine receptors with sulpiride, resulted in the enhancement of the excitatory effect, and the abolition of the inhibitory effect. Dopamine caused hyperpolarization and masked the inhibitory phase of L-DOPA action. The results show that precursors affect the rate of firing of isolated monoaminergic neurons and that their effect is completely or partially mediated by the enhanced synthesis of the respective neurotransmitter, followed by extrasynaptic release of the latter and activation of extrasynaptic autoreceptors.
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