ArticleCell research2009
PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation.
Article in Cell research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.Science advances · 2021Article
- Neuroendocrine Assessment of Dopaminergic Function during Antidepressant Treatment in Major Depressed Patients.Brain sciences · 2021Article
- GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.CNS neuroscience & therapeutics · 2017Article
- Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts.EBioMedicine · 2016Article
- MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective.Molecular neurobiology · 2015Review
- New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease.Frontiers in biology · 2015Article
- Postsynaptic Density Protein 95 in the Striosome and Matrix Compartments of the Human Neostriatum.Frontiers in neuroanatomy · 2015Article
- Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.British journal of pharmacology · 2014Article
- Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.Molecular neurobiology · 2014Review
- Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization.The Journal of biological chemistry · 2012Article
- Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.British journal of pharmacology · 2012Review
- Dopamine and renal function and blood pressure regulation.Comprehensive Physiology · 2011Review
- Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.Journal of neurogeneticsArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The present study aims to define the role of postsynaptic density (PSD)-95 in the regulation of dopamine (DA) receptor function. We found that PSD-95 physically associates with either D(1) or D(2) DA receptors in co-transfected HEK-293 cells. Stimulation of DA receptors altered the association between D(1) receptor and PSD-95 in a time-dependent manner. Functional assays indicated that PSD-95 co-expression did not affect D(1) receptor-stimulated cAMP production, Gs-protein activation or receptor desensitization. However, PSD-95 accelerated the recovery of internalized membrane receptors by promoting receptor recycling, thus resulting in enhanced resensitization of internalized D(1) receptors. Our results provide a novel mechanism for regulating DA receptor recycling that may play an important role in postsynaptic DA functional modulation and synaptic neuroplasticity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.