ArticleProceedings of the National Academy of Sciences of the United States of America2009
Localization of a bacterial cytoplasmic receptor is dynamic and changes with cell-cell contacts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Mutation Rate and Effective Population Size of the Model Cooperative Bacterium Myxococcus xanthus.Genome biology and evolution · 2024Article
- Hs27 fibroblast response to contact guidance cues.Scientific reports · 2023Article
- Whole-Genome Sequence ofMicrobiology resource announcements · 2023Article
- Defining Two Chemosensory Arrays inBiomolecules · 2022Article
- Complete Genome Sequence ofMicrobiology resource announcements · 2021Article
- Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors.Biophysical journal · 2018Article
- A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus.Nature microbiology · 2018Article
- Sensory Repertoire of Bacterial Chemoreceptors.Microbiology and molecular biology reviews : MMBR · 2017Review
- The nucleoid as a scaffold for the assembly of bacterial signaling complexes.PLoS genetics · 2017Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
- Hypothetical Protein BB0569 Is Essential for Chemotaxis of the Lyme Disease Spirochete Borrelia burgdorferi.Journal of bacteriology · 2015Article
- How Myxobacteria Cooperate.Journal of molecular biology · 2015Review
- Chemotaxis Control of Transient Cell Aggregation.Journal of bacteriology · 2015Review
- The cognitive cell: bacterial behavior reconsidered.Frontiers in microbiology · 2015Review
- Internal sense of direction: sensing and signaling from cytoplasmic chemoreceptors.Microbiology and molecular biology reviews : MMBR · 2014Review
- Space-induced bifurcation in repression-based transcriptional circuits.BMC systems biology · 2014Article
- Cell division resets polarity and motility for the bacterium Myxococcus xanthus.Journal of bacteriology · 2014Article
- Transmission of a signal that synchronizes cell movements in swarms of Myxococcus xanthus.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Chemosensory regulation of a HEAT-repeat protein couples aggregation and sporulation in Myxococcus xanthus.Journal of bacteriology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Directional motility in the gliding bacterium Myxococcus xanthus requires controlled cell reversals mediated by the Frz chemosensory system. FrzCD, a cytoplasmic chemoreceptor, does not form membrane-bound polar clusters typical for most bacteria, but rather cytoplasmic clusters that appear helically arranged and span the cell length. The distribution of FrzCD in living cells was found to be dynamic: FrzCD was localized in clusters that continuously changed their size, number, and position. The number of FrzCD clusters was correlated with cellular reversal frequency: fewer clusters were observed in hypo-reversing mutants and additional clusters were observed in hyper-reversing mutants. When moving cells made side-to-side contacts, FrzCD clusters in adjacent cells showed transient alignments. These events were frequently followed by one of the interacting cells reversing. These observations suggest that FrzCD detects signals from a cell contact-sensitive signaling system and then re-localizes as it directs reversals to distributed motility engines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.