ArticleProceedings of the National Academy of Sciences of the United States of America2009
The homology recognition well as an innate property of DNA structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Imaging and mechanism of DNA-DNA recognition mediated by divalent ions.Nucleic acids research · 2026Article
- Helical correlations in curved DNA condensates.Nucleic acids research · 2025Article
- Homologous pairing in short double-stranded DNA-grafted colloidal microspheres.Biophysical journal · 2022Article
- Nucleosome-induced homology recognition in chromatin.Journal of the Royal Society, Interface · 2021Article
- On the Mechanism of Homology Search by RecA Protein Filaments.Biophysical journal · 2017Article
- Mechanisms of fast and stringent search in homologous pairing of double-stranded DNA.PLoS computational biology · 2017Article
- Evidence of protein-free homology recognition in magnetic bead force-extension experiments.Proceedings. Mathematical, physical, and engineering sciences · 2016Article
- DNA under Force: Mechanics, Electrostatics, and Hydration.Nanomaterials (Basel, Switzerland) · 2015Review
- Stress-induced condensation of bacterial genomes results in re-pairing of sister chromosomes: implications for double strand DNA break repair.The Journal of biological chemistry · 2013Article
- Effects of pulling forces, osmotic pressure, condensing agents and viscosity on the thermodynamics and kinetics of DNA ejection from bacteriophages to bacterial cells: a computational study.Journal of physics. Condensed matter : an Institute of Physics journal · 2013Article
- Bullied no more: when and how DNA shoves proteins around.Quarterly reviews of biophysics · 2012Review
- Signatures of DNA flexibility, interactions and sequence-related structural variations in classical X-ray diffraction patterns.Nucleic acids research · 2011Article
- Undulations enhance the effect of helical structure on DNA interactions.The journal of physical chemistry. B · 2010Article
- Single molecule detection of direct, homologous, DNA/DNA pairing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Electric Field of DNA in Solution: Who Is in Charge?Physical review. XArticle
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2 authors.
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Abstract
Mutual recognition of homologous sequences of DNA before strand exchange is considered to be the most puzzling stage of recombination of genes. In 2001, a mechanism was suggested for a double-stranded DNA molecule to recognize from a distance its homologous match in electrolytic solution without unzipping [Kornyshev AA, Leikin S (2001) Phys Rev Lett 86:3666-3669]. Based on a theory of electrostatic interactions between helical molecules, the difference in the electrostatic interaction energy between homologous duplexes and between nonhomologous duplexes, called the recognition energy, was calculated. Here, we report a theoretical investigation of the form of the potential well that DNA molecules may feel sliding along each other. This well, the bottom of which is determined by the recognition energy, leads to trapping of the molecular tracks of the same homology in direct juxtaposition. A simple formula for the shape of the well is obtained. The well is quasi-exponential. Its half-width is determined by the helical coherence length, introduced first in the same 2001 article, the value of which, as the latest study shows, is approximately 10 nm.
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