ArticleAntimicrobial agents and chemotherapy2009
Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.PloS one · 2018Pooled it
- A meta-analysis of the proportion of animal Salmonella isolates resistant to drugs used against human salmonellosis in Ethiopia.BMC infectious diseases · 2015Pooled it
- A meta-analysis of the proportion of antimicrobial resistant human Salmonella isolates in Ethiopia.BMC pharmacology & toxicology · 2014Pooled it
- Prevalence of human Salmonellosis in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2014Pooled it
- Fitness costs of Tn1546-type transposons harboring the vanA operon by plasmid type and structural diversity in Enterococcus faecium.Annals of clinical microbiology and antimicrobials · 2024Article
- Accumulation of resistance genes inApplied and environmental microbiology · 2024Article
- Anthropogenic contamination sources drive differences in antimicrobial-resistantApplied and environmental microbiology · 2024Article
- A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.Nature communications · 2023Review
- Portable Differential Detection of CTX-M ESBL Gene Variants,Microbiology spectrum · 2023Article
- The biogenesis of β-lactamase enzymes.Microbiology (Reading, England) · 2022Review
- Formation, Transmission, and Dynamic Evolution of a Multidrug-Resistant Chromosomally Integrated Plasmid inFrontiers in microbiology · 2022Article
- Transmission of extended-spectrum cephalosporin-resistant Salmonella harboring a blaThe Journal of veterinary medical science · 2021Article
- Novel chromosomal insertions of ISEcp1-blaAntimicrobial resistance and infection control · 2021Article
- Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-ResistantApplied and environmental microbiology · 2020Article
- Transferable Mechanisms of Quinolone Resistance from 1998 Onward.Clinical microbiology reviews · 2019Review
- The Role of Plasmids in the Multiple Antibiotic Resistance Transfer in ESBLs-ProducingFrontiers in microbiology · 2019Article
- The Emergence of Chromosomally LocatedFrontiers in microbiology · 2019Article
- Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidalAntimicrobial resistance and infection control · 2017Article
- The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3.The Journal of antimicrobial chemotherapy · 2016Article
- High Prevalence of Chromosomal blaCTX-M-14 in Escherichia coli Isolates Possessing blaCTX-M-14.Antimicrobial agents and chemotherapy · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the emergence of Salmonella enterica isolates of serotype Concord (and its monophasic variant 6,7:l,v:-) producing the extended-spectrum beta-lactamases (ESBLs) SHV-12 and CTX-M-15 in France and Norway between 2001 and 2006 (43 in France and 26 in Norway). The majority of these isolates were from adopted children from Ethiopia, most of whom were healthy carriers. Several symptomatic secondary cases were found in the adoptive families and health care facilities in France. Serotype Concord isolates collected before 2003 produced SHV-12 encoded on a 340-kb conjugative plasmid of replicon IncI1. Isolates collected after 2003 produced CTX-M-15. We detected two conjugative plasmids carrying bla(CTX-M-15). One plasmid, approximately 300 kb in size, was positive for the IncHI2 replicon and the plasmid-mediated quinolone resistance gene qnrA1. The other plasmid, from one of the earliest CTX-M-15-producing isolates collected, was a fusion plasmid with IncY and IncA/C(2) replicons and was 200 kb in size. However, we showed, using Southern hybridization of I-CeuI-digested chromosomal DNA and S1 nuclease analysis of plasmid DNA, that most isolates had a bla(CTX-M-15) gene located on chromosomal DNA. Analysis of the flanking regions of the chromosomally located bla(CTX-M-15) gene by cloning revealed an ISEcp1 truncated by an intact IS26 upstream from the bla(CTX-M-15) gene and a truncated orf477 gene downstream from bla(CTX-M-15). We found regions beyond the IS26 and the orf477 genes that were derived from IncA/C(2) plasmids, suggesting the chromosomal integration of part of the bla(CTX-M-15)-carrying IncY and IncA/C(2) fusion plasmid from early CTX-M-15-producing isolates.
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