ArticleThe Journal of cell biology2009
Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- A single-cell atlas of alternative wing development in two hemipteran species.Nature communications · 2026Article
- Bicoid-nucleosome competition sets a concentration threshold for transcription constrained by genome replication.Cell reports · 2025Article
- Article
- Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila.Nature communications · 2022Article
- Article
- Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.PLoS genetics · 2020Article
- Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.PLoS biology · 2020Article
- Spindle Architectural Features Must Be Considered Along With Cell Size to Explain the Timing of Mitotic Checkpoint Silencing.Frontiers in physiology · 2020Article
- Setting up for gastrulation: D. melanogaster.Current topics in developmental biology · 2020Review
- Review
- A Cyclin A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles.PLoS genetics · 2019Article
- Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.PloS one · 2018Article
- Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.The Journal of cell biology · 2017Article
- Distinct and Overlapping Requirements for Cyclins A, B, and B3 inG3 (Bethesda, Md.) · 2016Article
- Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.Developmental cell · 2016Article
- Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.Current biology : CB · 2015Article
- The biochemistry of mitosis.Cold Spring Harbor perspectives in biology · 2015Review
- Spatial reorganization of the endoplasmic reticulum during mitosis relies on mitotic kinase cyclin A in the early Drosophila embryo.PloS one · 2015Article
- Untangling the web: the diverse functions of the PIWI/piRNA pathway.Molecular reproduction and development · 2013Review
- Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.The Journal of cell biology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cyclins are key cell cycle regulators, yet few analyses test their role in timing the events that they regulate. We used RNA interference and real-time visualization in embryos to define the events regulated by each of the three mitotic cyclins of Drosophila melanogaster, CycA, CycB, and CycB3. Each individual and pairwise knockdown results in distinct mitotic phenotypes. For example, mitosis without metaphase occurs upon knockdown of CycA and CycB. To separate the role of cyclin levels from the influences of cyclin type, we knocked down two cyclins and reduced the gene dose of the one remaining cyclin. This reduction did not prolong interphase but instead interrupted mitotic progression. Mitotic prophase chromosomes formed, centrosomes divided, and nuclei exited mitosis without executing later events. This prompt but curtailed mitosis shows that accumulation of cyclin function does not directly time mitotic entry in these early embryonic cycles and that cyclin function can be sufficient for some mitotic events although inadequate for others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.