ArticleMolecular and cellular biology2009
AU-rich elements regulate Drosophila gene expression.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.Nature communications · 2022Article
- Basal hsp70 expression levels do not explain adaptive variation of the warm- and cold-climate OBMC evolutionary biology · 2020Article
- Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila.Cell reports · 2018Article
- Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations.Scientific reports · 2018Article
- Tis11 mediated mRNA decay promotes the reacquisition of Drosophila intestinal stem cell quiescence.Developmental biology · 2017Article
- RNA binding proteins as regulators of immune cell biology.Clinical and experimental immunology · 2016Review
- Dynamic regulation of mRNA decay during neural development.Neural development · 2015Article
- Single-molecule modeling of mRNA degradation by miRNA: Lessons from data.BMC systems biology · 2015Article
- The Drosophila Tis11 protein and its effects on mRNA expression in flies.The Journal of biological chemistry · 2014Article
- Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.Molecular and cellular biology · 2014Article
- The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.Development (Cambridge, England) · 2014Article
- Article
- dTIS11 Protein-dependent polysomal deadenylation is the key step in AU-rich element-mediated mRNA decay in Drosophila cells.The Journal of biological chemistry · 2012Article
- Genome-wide assessment of AU-rich elements by the AREScore algorithm.PLoS genetics · 2012Article
- Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11.International journal of biological sciences · 2012Article
- Article
- Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.Molecular systems biology · 2011Article
- MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.Molecular and cellular biology · 2011Article
- Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila.PLoS genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, AU-rich elements (AREs) are critical regulators of mRNA turnover. They recruit ARE-binding proteins that inhibit or stimulate rapid mRNA degradation in response to stress or developmental cues. Using a bioinformatics approach, we have identified AREs in Drosophila melanogaster 3' untranslated regions and validated their cross-species conservation in distant Drosophila genomes. We have generated a Drosophila ARE database (D-ARED) and established that about 16% of D. melanogaster genes contain the mammalian ARE signature, an AUUUA pentamer in an A/U-rich context. Using candidate ARE genes, we show that Drosophila AREs stimulate reporter mRNA decay in cultured cells and in the physiological context of the immune response in D. melanogaster. In addition, we found that the conserved ARE-binding protein Tis11 regulates temporal gene expression through ARE-mediated decay (AMD) in D. melanogaster. Our work reveals that AREs are conserved and functional cis regulators of mRNA decay in Drosophila and highlights this organism as a novel model system to unravel in vivo the contribution of AMD to various processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.