ReviewThe Journal of physiology2009
Developmental alterations in the functional properties of excitatory neocortical synapses.
Review in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Spontaneous synchronous network activity in the neonatal development of mPFC in mice.Developmental neurobiology · 2021Article
- Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex.Scientific reports · 2019Article
- Developmental Easing of Short-Term Depression in "Winner" Climbing Fibers.Frontiers in cellular neuroscience · 2019Article
- Developmental Increase of Neocortical Presynaptic EfficacyFrontiers in synaptic neuroscience · 2019Article
- Developmental Emergence of Sparse Coding: A Dynamic Systems Approach.Scientific reports · 2017Article
- Mechanisms of Hierarchical Cortical Maturation.Frontiers in cellular neuroscience · 2017Review
- Decreasing-Rate Pruning Optimizes the Construction of Efficient and Robust Distributed Networks.PLoS computational biology · 2015Article
- Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Short-term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA1 pyramidal cells.The European journal of neuroscience · 2015Article
- Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Developmental tightening of cerebellar cortical synaptic influx-release coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors.Frontiers in synaptic neuroscience · 2015Article
- Expression of Npas4 mRNA in Telencephalic Areas of Adult and Postnatal Mouse Brain.Frontiers in neuroanatomy · 2015Article
- The anatomical problem posed by brain complexity and size: a potential solution.Frontiers in neuroanatomy · 2015Article
- The developmental stages of synaptic plasticity.The Journal of physiology · 2014Review
- Emergence of adaptive computation by single neurons in the developing cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength.The Journal of physiology · 2013Article
- Rethinking schizophrenia in the context of normal neurodevelopment.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the neocortex, most excitatory, glutamatergic synapses are established during the first 4-5 weeks after birth. During this period profound changes in the properties of synaptic transmission occur. Excitatory postsynaptic potentials (EPSPs) at immature synaptic connections are profoundly and progressively reduced in response to moderate to high frequency (5-100 Hz) stimulation. With maturation, this frequency-dependent depression becomes progressively weaker and may eventually transform into a weak to moderate EPSP facilitation. In parallel to changes in the short-term plasticity, a reduction in the synaptic reliability occurs at most glutamatergic neocortical synapses: immature synapses show a high probability of neurotransmitter release as indicated by their low failure rate and small EPSP amplitude variation. This high reliability is reduced in mature synapses, which show considerably higher failure rates and more variable EPSP amplitudes. During early neocortical development synaptic vesicle pools are not yet fully differentiated and their replenishment may be slow, thus resulting in EPSP amplitude depression. The decrease in the probability of neurotransmitter release may be the result of an altered Ca(2+) control in the presynaptic terminal with a reduced Ca(2+) influx and/or a higher Ca(2+) buffering capacity. This may lead to a lower synaptic reliability and a weaker short-term synaptic depression with maturation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.