ReviewFrontiers in bioscience (Landmark edition)2009
Neuropeptides in tendinopathy.
Review in Frontiers in bioscience (Landmark edition), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Is neurogenic inflammation involved in tendinopathy? A systematic review.BMJ open sport & exercise medicine · 2023Pooled it
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Neural Markers Predict Tendon Healing Outcomes in an Ovine Achilles Tendon Injury Model: Spontaneous Repair Versus Amniotic Epithelial Cell-Induced Regeneration.International journal of molecular sciences · 2025Article
- Predictive Neuromarker Patterns for Calcification Metaplasia in Early Tendon Healing.Veterinary sciences · 2024Article
- The roles and therapeutic potentialof mesenchymal stem/stromal cells and their extracellular vesicles in tendinopathies.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons.International journal of molecular sciences · 2021Article
- The analgesic effect of joint mobilization and manipulation in tendinopathy: a narrative review.The Journal of manual & manipulative therapy · 2021Review
- Human Tendon Stem/Progenitor Cell Features and Functionality Are Highly Influenced byFrontiers in bioengineering and biotechnology · 2021Article
- Tendinosis-like changes in denervated rat Achilles tendon.BMC musculoskeletal disorders · 2018Article
- The roles of inflammatory mediators and immunocytes in tendinopathy.Journal of orthopaedic translation · 2018Review
- Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies.American journal of translational research · 2017Review
- WHY ARE ECCENTRIC EXERCISES EFFECTIVE FOR ACHILLES TENDINOPATHY?International journal of sports physical therapy · 2015Article
- Increased mast cell numbers in a calcaneal tendon overuse model.Scandinavian journal of medicine & science in sports · 2013Article
- Current concepts in examination and treatment of elbow tendon injury.Sports health · 2013Article
- Tendinopathy in sport.Sports health · 2012Article
- Sodium cromolyn reduces expression of CTGF, ADAMTS1, and TIMP3 and modulates post-injury patellar tendon morphology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted the role of sensory and autonomic nerves in generating or perpetuating the symptoms and tissue abnormalities associated with tendinopathy. We outline the neuroanatomy and potential roles of nerves and associated neuropeptides in tendinopathy. In addition, intriguing new data is reviewed which suggests that there may be a substantial intrinsic source of neuropeptides within tendons - namely, the tenocytes themselves. The potential roles of Substance P and mast cells are highlighted in particular. We discuss the implications for conservative management including sclerosing injections and exercise training.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.