Evidence map›Paper›PMID 19273150›Full record

ReviewFrontiers in bioscience (Landmark edition)2009

RNA-protein interactions in hepadnavirus reverse transcription.

Jianming Hu, Li Lin

Open access · bronzeAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Analysis of hepatocellular carcinoma associated with hepatitis B virus.Journal of cellular and molecular medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jianming HuDepartment of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. juh13@psu.edu
Li Lin
Pennsylvania State University · US

Funding

MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATIONR01AI043453 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HU, JIANMING · 1999 to 2017
$5.9M
Mechanisms of Hepadnavirus Assembly and ReplicationR37AI043453 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Jianming Hu · 2018 to 2026
$3.8M
NIAID NIH HHS R01 AI043453NIAID NIH HHS R01 AI43453NIAID NIH HHS R37 AI043453
6 · The paper itself

Abstract

The small DNA genome of hepadnaviruses is replicated by reverse transcription via an RNA intermediate. This RNA "pregenome" contains important signals that control critical steps of viral replication, including RNA packaging, initiation of reverse transcription, and elongation of minus strand DNA, through specific interactions with the viral reverse transcriptase, the capsid protein, and host factors. In particular, the interaction between the viral reverse transcriptase and RNA pregenome requires a host chaperone complex composed of the heat shock protein 90 and its cochaperones.

Indexed as

Genes, ViralTranscription, GeneticDNA, ViralHepadnaviridaeRNA-Binding ProteinsRNA, ViralDNA, ViralRNA-Binding ProteinsRNA, Viral

Identifiers

PMID19273150
PMCPMC3611959
OpenAlexW2058333731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.