ReviewFrontiers in bioscience (Landmark edition)2009
Therapeutic interventions and oxidative stress in diabetes.
Review in Frontiers in bioscience (Landmark edition), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Relationship Between Hypovitaminosis C, Obesity, and Features of Metabolic Syndrome-A Narrative Review.Nutrition reviews · 2026Review
- Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis.International journal of molecular sciences · 2025Review
- Sleep Apnea, Obesity, and Diabetes - an Intertwined Trio.Current diabetes reports · 2023Review
- The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin DAntioxidants (Basel, Switzerland) · 2020Article
- Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production.Scientific reports · 2019Article
- Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro.Medical science monitor basic research · 2014Article
- MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Impairment of pancreatic β-cell function by chronic intermittent hypoxia.Experimental physiology · 2013Article
- Article
- Hydrogen sulfide in biochemistry and medicine.Antioxidants & redox signaling · 2012Review
- Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies.Journal of bioenergetics and biomembranes · 2012Review
- Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus.Obesity (Silver Spring, Md.) · 2011Article
- Thiol signalling network with an eye to diabetes.Molecules (Basel, Switzerland) · 2010Review
- Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different.Redox report : communications in free radical research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many therapeutic agents that are used in patients with diabetes mitigate oxidative stress. These agents are of particular interest because oxidative stress is elevated in diabetes and is thought to contribute to vascular dysfunction. Agents that merely quench already formed reactive oxygen species have demonstrated limited success in improving cardiovascular outcomes. Thus, although vitamin E, C, and alpha lipoic acid appeared promising in animal models and initial human studies, subsequent larger trials have failed to demonstrate improvement in cardiovascular outcomes. Drugs that limit the production of oxidative stress are more successful in improving vascular outcomes in patients with diabetes. Thus, although statins, ACE inhibitors, ARBs and thiazolinediones are used for varied clinical purposes, their increased efficacy in improving cardiovascular outcomes is likely related to their success in reducing the production of reactive oxygen species at an earlier part of the cascade, thereby more effectively decreasing the oxidative stress burden. In particular, statins and ACE inhibitors/ ARBs appear the most successful at reducing oxidative stress and vascular disease and have potential for synergistic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.