ArticleIEEE transactions on bio-medical engineering2009
Quantifying acute myocardial injury using ratiometric fluorometry.
Article in IEEE transactions on bio-medical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium.Biomolecules · 2022Article
- Three-dimensional vascular and metabolic imaging using inverted autofluorescence.Journal of biomedical optics · 2021Article
- Optical Metabolic Imaging of Mitochondrial Dysfunction on HADH Mutant Newborn Rat Hearts.IEEE journal of translational engineering in health and medicine · 2021Article
- In vivo label-free optical monitoring of structural and metabolic remodeling of myocardium following infarction.Biomedical optics express · 2019Article
- Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury.Journal of biomedical optics · 2018Article
- The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging.Neurobiology of aging · 2016Article
- Application of time-resolved autofluorescence to label-free in vivo optical mapping of changes in tissue matrix and metabolism associated with myocardial infarction and heart failure.Biomedical optics express · 2015Article
- Optical cryoimaging of mitochondrial redox state in bronchopulmonary-dysplasia injury models in mice lungs.Quantitative imaging in medicine and surgery · 2015Article
- Optical imaging of mitochondrial redox state in rodent models with 3-iodothyronamine.Experimental biology and medicine (Maywood, N.J.) · 2014Article
- Reactive oxygen species and redox compartmentalization.Frontiers in physiology · 2014Review
- OPTICAL IMAGING OF LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN ACUTE LUNG INJURY FROM HYPEROXIA AND SEPSIS.Journal of innovative optical health sciences · 2013Article
- Surface fluorescence studies of tissue mitochondrial redox state in isolated perfused rat lungs.Annals of biomedical engineering · 2013Article
- Optical imaging of mitochondrial redox state in rodent model of retinitis pigmentosa.Journal of biomedical optics · 2013Article
- Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress.Journal of biomedical optics · 2012Article
- Mitochondrial redox studies of oxidative stress in kidneys from diabetic mice.Biomedical optics express · 2012Article
- PROBING THE IMPACT OF GAMMA-IRRADIATION ON THE METABOLIC STATE OF NEURAL STEM AND PRECURSOR CELLS USING DUAL-WAVELENGTH INTRINSIC SIGNAL TWO-PHOTON EXCITED FLUORESCENCE.Journal of innovative optical health sciences · 2011Article
- High-sensitive fluorescence endoscope using electrocardiograph-synchronized multiple exposure.International journal of computer assisted radiology and surgery · 2011Article
- In vivo fluorometric assessment of cyclosporine on mitochondrial function during myocardial ischemia and reperfusion.The Annals of thoracic surgery · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Early reperfusion is the best therapy for myocardial infarction (MI). Effectiveness, however, varies significantly between patients and has implications for long-term prognosis and treatment. A technique to assess the extent of myocardial salvage after reperfusion therapy would allow for high-risk patients to be identified in the early post-MI period. Mitochondrial dysfunction is associated with cell death following myocardial reperfusion and can be quantified by fluorometry. Therefore, we hypothesized that variations in the fluorescence of mitochondrial nicotinamide adenine dinucleotide (NADH) and flavoprotein (FP) can be used acutely to predict the degree of myocardial injury. Thirteen rabbits had coronary occlusion for 30 min followed by 3 h of reperfusion. To produce a spectrum of infarct sizes, six animals were infused cyclosporine A prior to ischemia. Using a specially designed fluorometric probe, NADH and FP fluorescence were measured in the ischemic area. Changes in NADH and FP fluorescence, as early as 15 min after reperfusion, correlated with postmortem assessment infarct size ( r = 0.695, p < 0.01). This correlation strengthened with time ( r = 0.827, p < 0.001 after 180 min). Clinical application of catheter-based myocardial fluorometry may provide a minimally invasive technique for assessing the early response to reperfusion therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.