ArticleGastroenterology2009
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 85 citations in OpenAlex.
- Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C).The Biochemical journal · 2025Review
- The TRP channels serving as chemical-to-electrical signal converter.Physiological reviews · 2025Review
- Effects of Cholinergic and Opioid Antagonists on In Vitro Release of Met-Enkephalin, Somatostatin and Insulin-like Growth Factor-1 by and PENK Expression in Crop, Proventriculus and Duodenum of Newly Hatched Chickens.Animals : an open access journal from MDPI · 2025Article
- Possible connection between intestinal tuft cells, ILC2s and obesity.Frontiers in immunology · 2023Review
- Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer.Oncology research · 2023Article
- Tuft Cells and Their Role in Intestinal Diseases.Frontiers in immunology · 2022Review
- An update on the biological characteristics and functions of tuft cells in the gut.Frontiers in cell and developmental biology · 2022Review
- Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction.Annual review of neuroscience · 2020Review
- Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.Scientific reports · 2019Article
- Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Luminal chemosensing in the gastroduodenal mucosa.Current opinion in gastroenterology · 2017Review
- Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.Cell stem cell · 2017Article
- Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system.Mucosal immunology · 2016Review
- Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.Histochemistry and cell biology · 2016Article
- Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.Cell and tissue research · 2016Article
- Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains.Scientific reports · 2016Article
- Article
- Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity.Frontiers in pharmacology · 2014Review
- TRPs in taste and chemesthesis.Handbook of experimental pharmacology · 2014Review
- Digestive physiology of the pig symposium: involvement of gut chemosensing in the regulation of mucosal barrier function and defense mechanisms.Journal of animal science · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsEnteroendocrine cells, the largest and most diverse population of mammalian endocrine cells, comprise a number of different cell types in the gut mucosa that produce, store, and secrete small molecules, peptides, and/or larger proteins that regulate many aspects of gut physiology. Little is known about less typical endocrine cells in the intestinal mucosa that do not contain secretory granules, such as brush or caveolated cells. We studied a subset of these enteroendocrine cells in duodenum that produce several peptides, including endogenous opioids, and that also express the Trpm5 cation channel.
methodsWe studied expression patterns of Trpm5 and other molecules by immunohistochemical and enzyme-linked immunosorbent assay analyses of intestinal tissues from transgenic mice that express green fluorescent protein from the Trpm5 promoter, as well as wild-type and Trpm5-null mice.
resultsWe describe a type of enteroendocrine cell in mouse duodenum that is defined by the presence of Trpm5 and that does not contain typical secretory granules yet expresses endogenous opioids (beta-endorphin and Met-enkephalin) and uroguanylin in apical compartments close to the lumen of the gut.
conclusionsSolitary chemosensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 exist in mouse duodenum. These cells are likely to secrete the bioactive peptides into the intestinal lumen in response to dietary factors; release of the opioid peptides requires the Trpm5 ion channel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.