ArticleDevelopmental biology2009
Paraxial mesoderm contributes stromal cells to the developing kidney.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Kidney organoid vascularization: current advancements in the field.Regenerative therapy · 2026Article
- Isocitrate Dehydrogenases Idh1 and Idh2 Regulate Pronephric Morphogenesis inDevelopment & reproduction · 2026Article
- The kidney stroma in development and disease.Nature reviews. Nephrology · 2025Review
- Somites are a source of nephron progenitors in zebrafish.Nature communications · 2025Article
- Vascularization of kidney organoids: different strategies and perspectives.Frontiers in urology · 2024Review
- Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation.Scientific reports · 2023Article
- Production of kidney organoids arranged around single ureteric bud trees, and containing endogenous blood vessels, solely from embryonic stem cells.Scientific reports · 2022Article
- Kidney organoids: current knowledge and future directions.Cell and tissue research · 2022Review
- The origin and role of the renal stroma.Development (Cambridge, England) · 2021Review
- Interactions between Muscle and Bone-Where Physics Meets Biology.Biomolecules · 2020Review
- Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid.Frontiers in cell and developmental biology · 2020Review
- Impaired intermediate formation in mouse embryos expressing reduced levels of Tbx6.Genesis (New York, N.Y. : 2000) · 2019Article
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
- Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.Development (Cambridge, England) · 2015Article
- Assembling Kidney Tissues from Cells: The Long Road from Organoids to Organs.Frontiers in cell and developmental biology · 2015Review
- osr1 is required for podocyte development downstream of wt1a.Journal of the American Society of Nephrology : JASN · 2014Article
- Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis.Stem cell reports · 2014Article
- Lineage-tracing methods and the kidney.Kidney international · 2014Review
- Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.Nature cell biology · 2014Article
- The genetics and epigenetics of kidney development.Seminars in nephrology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The development of most, if not all, tubular organs is dependent on signaling between epithelial and stromal progenitor populations. Most often, these lineages derive from different germ layers that are specified during gastrulation, well in advance of organ condensation. Thus, one of the first stages of organogenesis is the integration of distinct progenitor populations into a single embryonic rudiment. In contrast, the stromal and epithelial lineages controlling renal development are both believed to derive from the intermediate mesoderm and to be specified as the kidney develops. In this study we directly analyzed the lineage of renal epithelia and stroma in the developing chick embryo using two independent fate mapping techniques. Results of these experiments confirm the hypothesis that nephron epithelia derive from the intermediate mesoderm. Most importantly, we discovered that large populations of renal stroma originate in the paraxial mesoderm. Collectively, these studies suggest that the signals that subdivide mesoderm into intermediate and paraxial domains may play a role in specifying nephron epithelia and a renal stromal lineage. In addition, these fate mapping data indicate that renal development, like the development of all other tubular organs, is dependent on the integration of progenitors from different embryonic tissues into a single rudiment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.