ReviewJournal of neurotrauma2009
Hypothermia following pediatric traumatic brain injury.
Review in Journal of neurotrauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Italian guidelines on the assessment and management of pediatric head injury in the emergency department.Italian journal of pediatrics · 2018Pooled it
- A Systematic Review of the Effects of Body Temperature on Outcome After Adult Traumatic Brain Injury.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2015Pooled it
- A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury.Critical care (London, England) · 2014Pooled it
- Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2013Trial
- Pediatric abusive head trauma.Biomedical journal · 2020Review
- Recent progress and future issues in the management of abusive head trauma.Neurologia medico-chirurgica · 2015Review
- Therapeutic Hypothermia in Children and Adults with Severe Traumatic Brain Injury.Therapeutic hypothermia and temperature management · 2014Review
- Pediatric neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Therapeutic hypothermia for acute neurological injuries.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- α-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia.Developmental neuroscience · 2010Article
- The Effect of Operating Room Temperature on the Performance of Clinical and Cognitive Tasks.Pediatric quality & safetyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Preclinical as well as clinical studies in traumatic brain injury (TBI) have established the likely association of secondary injury and outcome in adults in children following severe injury. Similarly, there is growing evidence in experimental laboratory studies that moderate hypothermia has a beneficial effect on outcome, though the exact mechanisms remain to be absolutely defined. The Pediatric TBI Guidelines provided the knowledge and background for standard management of children following severe TBI and highlighted that there are very few clinical studies to date. In particular with respect to temperature regulation and the use of hypothermia, initial findings of case series of small numbers were promising. Further preliminary randomized clinical trials, both single institution and multicenter, have provided the initial data on safety and efficacy, though larger, Phase III studies are necessary to ensure both the safety and efficacy of hypothermia in pediatric TBI prior to implementation as part of the standard of care. It is expected that hypothermia initiated early after severe TBI will have a protective effect on the pediatric brain and can be done safely, but this still remains to be definitively tested.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.