ArticleJournal of neurotrauma2009
Environmental experience modulates ischemia-induced amyloidogenesis and enhances functional recovery.
Article in Journal of neurotrauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy.British journal of pharmacology · 2019Review
- Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors.Cell transplantation · 2017Review
- Behavioral Neuroadaptation to Alcohol: From Glucocorticoids to Histone Acetylation.Frontiers in psychiatry · 2016Review
- Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling.Neuropathology and applied neurobiology · 2015Article
- Synaptic activity and Alzheimer's disease: a critical update.Frontiers in neuroscience · 2015Article
- Article
- Dysregulation in myelination mediated by persistent neuroinflammation: possible mechanisms in chemotherapy-related cognitive impairment.Brain, behavior, and immunity · 2014Article
- Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis.Neuroscience · 2013Article
- Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function.Acta neuropathologica communications · 2013Article
- Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden.Journal of neuroinflammation · 2012Article
- Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications.BMC neuroscience · 2011Article
- Are we studying and treating schizophrenia correctly?Schizophrenia research · 2011Article
- The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study.Frontiers in neuroscience · 2011Article
- Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury.Journal of neurotrauma · 2010Article
- Association between long-term cognitive decline in Vietnam veterans with TBI and caregiver attachment style.The Journal of head trauma rehabilitationObservational
Corrections and comments
- Retraction · 2015-05-27Duplication of/in Image · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Misconduct by Author ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we examined whether ischemia-induced amyloidogenesis could be modulated by environmental "experience," and whether this modulation is associated with improved cognitive functioning. Rats were subjected to either global ischemia or sham surgery and then were randomly assigned to either enriched environment housing (EE) or socially paired housing (controls). After 14 days of differential environmental housing, the rats were tested in the water maze. Our results show decreased C-terminal fragments of the beta-amyloid precursor protein (betaAPP) and decreased amyloid beta (Abeta) load in the ischemic EE rats compared to the ischemic control animals. In addition, Abeta oligomerization was significantly decreased in the ischemic EE animals compared to the ischemic control rats. Further, significantly increased levels of neprilysin, but not insulin-degrading enzyme, amyloid-degrading enzymes, were seen in the ischemic EE rats compared to the ischemic control animals. Behavioral analyses showed that ischemic EE rats performed significantly better on the memory task compared to the ischemic control group. These results suggest that use of multi-sensory environmental enrichment following cerebral ischemia may reduce the accumulation of Abeta peptide in the more pathologic oligomeric form, and consequently may enhance functional recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.