Penetration of antibacterials into bone: what do we really need to know for optimal prophylaxis and treatment of bone and joint infections?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

1. CarboCell G/C provides sustained high local bone antibiotic levels with minimal systemic exposure, supporting its therapeutic potential in orthopedic infection management.Journal of bone and joint infection · 2026
   Article
2. Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin: Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis.Antibiotics (Basel, Switzerland) · 2022
   Article
3. Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice.Antibiotics (Basel, Switzerland) · 2022
   Review
4. Orthopaedic Implant-Associated Staphylococcal Infections: A Critical Reappraisal of Unmet Clinical Needs Associated with the Implementation of the Best Antibiotic Choice.Antibiotics (Basel, Switzerland) · 2022
   Article
5. Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors.Drug delivery and translational research · 2021
   Review
6. Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study.Acta orthopaedica · 2018
   Article
7. Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients.Acta orthopaedica · 2018
   Article
8. Pharmacokinetics of cefuroxime in porcine cortical and cancellous bone determined by microdialysis.Antimicrobial agents and chemotherapy · 2014
   Article

Corrections and comments

• Commented on by
  Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.2009

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as