ReviewEuropean journal of pediatrics2009
Clinical practice. Diagnosis and treatment of cow's milk allergy.
Review in European journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 86 citations in OpenAlex.
- A thickened amino-acid formula in infants with cow's milk allergy failing to respond to protein hydrolysate formulas: a randomized double-blind trial.Paediatric drugs · 2014Trial
- Cow's Milk Protein Allergy: ETAPA Survey on Pediatric Management and Tolerance Acquisition.Children (Basel, Switzerland) · 2025Article
- Differential Cytokine Expression in the Duodenum and Rectum of Children with Non-Immunoglobulin E-Mediated Cow's Milk Protein Allergy.Digestive diseases and sciences · 2021Article
- Cow's Milk Allergy: Immunomodulation by Dietary Intervention.Nutrients · 2019Review
- Immunomodulatory Protein Hydrolysates and Their Application.Nutrients · 2018Review
- Article
- Relative cost-effectiveness of using an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in Poland.ClinicoEconomics and outcomes research : CEOR · 2016Article
- Hydrolysis with Cucurbita ficifolia serine protease reduces antigenic response to bovine whey protein concentrate and αs-casein.Amino acids · 2015Article
- Remaining symptoms in half the children treated for milk allergy.European journal of pediatrics · 2015Observational
- Relative cost-effectiveness of using an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in Spain.ClinicoEconomics and outcomes research : CEOR · 2015Article
- Biochemical markers of bone metabolism in children with cow's milk allergy.Archives of medical science : AMS · 2014Article
- Suspected cow's milk allergy in everyday general practice: a retrospective cohort study on health care burden and guideline adherence.BMC research notes · 2014Article
- Impact of cow's milk allergy on enterocolitis associated with Hirschsprung's disease.Pediatric surgery international · 2013Article
- The Potential Therapeutic Efficacy of Lactobacillus GG in Children with Food Allergies.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Diagnosis and management of cow's milk protein allergy in infants.World journal of pediatrics : WJP · 2012Review
- Camel milk is a safer choice than goat milk for feeding children with cow milk allergy.ISRN allergy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCow's milk allergy (CMA) is thought to affect 2-3% of infants. The signs and symptoms are nonspecific and may be difficult to objectify, and as the diagnosis requires cow's milk elimination followed by challenge, often, children are considered cow's milk allergic without proven diagnosis. DIAGNOSIS: Because of the consequences, a correct diagnosis of CMA is pivotal. Open challenges tend to overestimate the number of children with CMA. The only reliable way to diagnose CMA is by double-blind, placebo-controlled challenge (DBPCFC). THERAPY: At present, the only proven treatment consists of elimination of cow's milk protein from the child's diet and the introduction of formulas based on extensively hydrolysed whey protein or casein; amino acid-based formula is rarely indicated. The majority of children will regain tolerance to cow's milk within the first 5 years of life.
conclusionsOpen challenges can be used to reject CMA, but for adequate diagnosis, DBPCFC is mandatory. In most children, CMA can be adequately treated with extensively hydrolysed whey protein or casein formulas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.