ArticleInvestigational new drugs2010
Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols.
Article in Investigational new drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Green and black tea in relation to gynecologic cancers.Molecular nutrition & food research · 2011Pooled it
- Trial
- Epigallocatechin gallate, folic acid, vitamin B12 and hyaluronic acid in the management of male Human Papilloma Virus Infection: A case series.SAGE open medical case reports · 2026Article
- Preventing Persistence of HPV Infection with Natural Molecules.Pathogens (Basel, Switzerland) · 2023Review
- The Major Constituent of Green Tea, Epigallocatechin-3-Gallate (EGCG), Inhibits the Growth of HPV18-Infected Keratinocytes by Stimulating Proteasomal Turnover of the E6 and E7 Oncoproteins.Pathogens (Basel, Switzerland) · 2021Article
- Increased Oxidative Stress Induced byOxidative medicine and cellular longevity · 2019Article
- Suppressive Effects of EGCG on Cervical Cancer.Molecules (Basel, Switzerland) · 2018Review
- Article
- PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma.International journal of nanomedicine · 2015Article
- Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer.Medical oncology (Northwood, London, England) · 2014Article
- The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in Siha cells: differences in their activity and mechanism of action.Molecules (Basel, Switzerland) · 2013Article
- Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.Biochemical pharmacology · 2011Review
- Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo.Investigational new drugs · 2011Article
- Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.Investigational new drugs · 2011Article
- Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China.Frontiers of medicine in China · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer is the second most common malignant neoplasm in women, in terms of both incidence and mortality rates worldwide. The polyphenolic constituents of tea (Camellia sinensis) have gained considerable attention because of its anti-cancer properties against a variety of cancers. Here we studied the effects of green and black tea polyphenols (GTP and BTP), on cellular proliferation and cell death in the SiHa cells (human cervical cancer) expressing the human papilloma virus (HPV)-16. The result showed that both GTP and BTP inhibited proliferation of cells in dose and time dependent manner. Cell cycle analysis showed anti-proliferative effect of GTP which is associated with an increase in the G2/M phase and apoptotic effect of BTP in 24 h treated SiHa cells. Further, on increase of incubation time for 48 h, GTP caused induction of apoptosis up to 20% of SiHa cells. The role GTP and BTP in apoptosis was further confirmed by reduction in mitochondrial membrane potential and increased levels of membrane phosphatidylserine. Thus, our data suggests that tea polyphenols exhibit anti-cancer potential against cervical cancer by inhibition of cell growth and induction of apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.