ArticleJournal of psychiatry & neuroscience : JPN2009
Cortical folding in patients with bipolar disorder or unipolar depression.
Article in Journal of psychiatry & neuroscience : JPN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis.Journal of psychiatry & neuroscience : JPN · 2020Pooled it
- Individualized DTI-ALPS Identifies Phase-Specific Glymphatic Dysfunction in Early-Stage Bipolar Disorder.Biomedicines · 2026Article
- Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics.Communications medicine · 2025Article
- Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Cortical signature of depressive symptoms in frontotemporal dementia: A surface-based analysis.Annals of clinical and translational neurology · 2023Article
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives.Translational psychiatry · 2022Review
- The genetic architecture of human cortical folding.Science advances · 2021Article
- A model of tension-induced fiber growth predicts white matter organization during brain folding.Nature communications · 2021Article
- Common functional localizers to enhance NHP & cross-species neuroscience imaging research.NeuroImage · 2021Article
- Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.Frontiers in neuroanatomy · 2021Article
- The reliability and heritability of cortical folds and their genetic correlations across hemispheres.Communications biology · 2020Article
- Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses.NeuroImage. Clinical · 2020Article
- Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network.Brain sciences · 2019Article
- Neurodevelopmental subtypes of bipolar disorder are related to cortical folding patterns: An international multicenter study.Bipolar disorders · 2018Article
- High levels of neuroticism are associated with decreased cortical folding of the dorsolateral prefrontal cortex.European archives of psychiatry and clinical neuroscience · 2017Article
- Identification of Early-Stage Alzheimer's Disease Using Sulcal Morphology and Other Common Neuroimaging Indices.PloS one · 2017Article
- Classifying MCI Subtypes in Community-Dwelling Elderly Using Cross-Sectional and Longitudinal MRI-Based Biomarkers.Frontiers in aging neuroscience · 2017Article
- Brain oscillations in bipolar disorder and lithium-induced changes.Neuropsychiatric disease and treatment · 2016Review
- Deviations in cortex sulcation associated with visual hallucinations in schizophrenia.Molecular psychiatry · 2015Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnalysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding.
methodsWe computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression).
resultsCompared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres. LIMITATIONS: We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results.
conclusionReduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface.
Indexed as
Identifiers
19270763PMC2647564W1514574906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.