ArticleEMBO reports2009
Fork regression is an active helicase-driven pathway in bacteriophage T4.
Article in EMBO reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Torsion is a dynamic regulator of DNA replication stalling and reactivation.Nature communications · 2025Article
- In vitro reconstitution of DNA replication initiated by genetic recombination: a T4 bacteriophage model for a type of DNA synthesis important for all cells.Molecular biology of the cell · 2019Article
- Replication Fork Breakage and Restart in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2018Review
- Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats.Nucleic acids research · 2017Article
- Bacteriophage T5 gene D10 encodes a branch-migration protein.Scientific reports · 2016Article
- Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase.Structure (London, England : 1993) · 2016Article
- Irc3 is a mitochondrial DNA branch migration enzyme.Scientific reports · 2016Article
- A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- DNA repair in cancer: emerging targets for personalized therapy.Cancer management and research · 2014Review
- DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks.Cold Spring Harbor perspectives in biology · 2013Review
- Interaction of T4 UvsW helicase and single-stranded DNA binding protein gp32 through its carboxy-terminal acidic tail.Journal of molecular biology · 2013Article
- Article
- Rho-dependent transcription termination is essential to prevent excessive genome-wide R-loops in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue.Nature communications · 2013Article
- Direct observation of stalled fork restart via fork regression in the T4 replication system.Science (New York, N.Y.) · 2012Article
- Replication forks stalled at ultraviolet lesions are rescued via RecA and RuvABC protein-catalyzed disintegration in Escherichia coli.The Journal of biological chemistry · 2012Article
- Functional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins.The Journal of biological chemistry · 2012Article
- Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives.Virology journal · 2010Review
- Response of the bacteriophage T4 replisome to noncoding lesions and regression of a stalled replication fork.Journal of molecular biology · 2010Article
- FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling.The EMBO journal · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Reactivation of stalled replication forks requires specialized mechanisms that can recognize the fork structure and promote downstream processing events. Fork regression has been implicated in several models of fork reactivation as a crucial processing step that supports repair. However, it has also been suggested that regressed forks represent pathological structures rather than physiological intermediates of repair. To investigate the biological role of fork regression in bacteriophage T4, we tested several mechanistic models of regression: strand exchange-mediated extrusion, topology-driven fork reversal and helicase-mediated extrusion. Here, we report that UvsW, a T4 branch-specific helicase, is necessary for the accumulation of regressed forks in vivo, and that UvsW-catalysed regression is the dominant mechanism of origin-fork processing that contributes to double-strand end formation. We also show that UvsW resolves purified fork intermediates in vitro by fork regression. Regression is therefore part of an active, UvsW-driven pathway of fork processing in bacteriophage T4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.