ArticleNature methods2009
Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.
Article in Nature methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025Review
- Intrauterine desensitization enables long term survival of human oligodendrocyte progenitor cells without immunosuppression.iScience · 2023Article
- Cell-Autonomous Processes That Impair Xenograft Survival into the Cerebellum.Cerebellum (London, England) · 2022Review
- Spontaneous Graft-Induced Dyskinesias Are Independent of 5-HT Neurons and Levodopa Priming in a Model of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Preclinical assessment of thrombin-preconditioned human Wharton's jelly-derived mesenchymal stem cells for neonatal hypoxic-ischaemic brain injury.Journal of cellular and molecular medicine · 2021Article
- Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing.Scientific reports · 2021Article
- Concise Review: Human-Animal Neurological Chimeras: Humanized Animals or Human Cells in an Animal?Stem cells (Dayton, Ohio) · 2019Review
- An immunocompetent mouse model of human glioblastoma.Oncotarget · 2017Article
- hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.Experimental neurology · 2016Article
- Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells?Neurogenesis (Austin, Tex.) · 2016Article
- Experimental study of vein subvolution combined with neural stem cells to repair sciatic neurologic defects in rats.International journal of clinical and experimental pathology · 2015Article
- Neonatal immune-tolerance in mice does not prevent xenograft rejection.Experimental neurology · 2014Article
- Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat.Stem cells translational medicine · 2014Article
- Stem cell transplantation for muscular dystrophy: the challenge of immune response.BioMed research international · 2014Review
- Article
- Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppression.Stem cells and development · 2013Article
- Neonatal desensitization does not universally prevent xenograft rejection.Nature methods · 2012Article
- Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation.Stem cells translational medicine · 2012Article
- Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations.Seminars in immunopathology · 2011Review
- Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.Nature protocols · 2011Article
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Authors and funding
9 authors.
Funding
Abstract
Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
Indexed as
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19270699What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.