ReviewCell cycle (Georgetown, Tex.)2009
Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives.
Review in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Monocyte count combined with GTVnx is an independent prognostic factor in non-metastatic nasopharyngeal carcinoma receiving radiotherapy.Frontiers in oncology · 2025Article
- Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Mechanical regulation of signal transduction in angiogenesis.Frontiers in cell and developmental biology · 2022Review
- Celecoxib Blocks Vasculogenic MimicryFrontiers in oncology · 2021Article
- FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.Nature communications · 2020Article
- Leukocytosis, prognosis biomarker in locally advanced head and neck cancer patients after chemoradiotherapy.Clinical and translational radiation oncology · 2018Article
- A perspective on the impact of radiation therapy on the immune rheostat.The British journal of radiology · 2017Review
- Radiation-induced immune responses: mechanisms and therapeutic perspectives.Blood research · 2016Review
- Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes on outcomes in lung stereotactic body radiotherapy.Current oncology (Toronto, Ont.) · 2016Article
- Opportunities and challenges of radiotherapy for treating cancer.Nature reviews. Clinical oncology · 2015Review
- The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence.Nature reviews. Cancer · 2015Review
- Linking the history of radiation biology to the hallmarks of cancer.Radiation research · 2014Review
- Parathyroid hormone-related protein drives a CD11b+Gr1+ cell-mediated positive feedback loop to support prostate cancer growth.Cancer research · 2013Article
- Strategies for optimizing the response of cancer and normal tissues to radiation.Nature reviews. Drug discovery · 2013Review
- Reciprocal complementation of the tumoricidal effects of radiation and natural killer cells.PloS one · 2013Article
- Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.Cancer research · 2012Article
- MMP-9 from sublethally irradiated tumor promotes Lewis lung carcinoma cell invasiveness and pulmonary metastasis.Oncogene · 2012Article
- Strategies to improve radiotherapy with targeted drugs.Nature reviews. Cancer · 2011Review
- The confluence of stereotactic ablative radiotherapy and tumor immunology.Clinical & developmental immunology · 2011Review
- Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis.Cancer research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this review, we highlight some of recent studies underscoring the importance of the tumor microenvironment, especially the role of bone marrow-derived myeloid cells, in restoring tumor growth after irradiation. Myeloid cells are hematopoietic cells that give rise to monocytes and macrophages in the peripheral blood and tissues. These cells have been shown to be proangiogenic in tumors promoting tumor growth. We also discuss our previously unpublished results on the effect of irradiation on the tumor vasculature including pericyte and basement membrane coverage to the endothelium of tumor blood vessels. We summarize the clinical significance of these studies including the use of MMP-9 inhibitors, administering white blood cell boosters, or planning safety margin of tumor volumes, in order to improve overall clinical benefits in cancer patients treated with radiotherapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.