ArticleJournal of lipid research2009
Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons.
Article in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Association Between ERBB2 and ERBB3 Polymorphisms and Dyslipidaemia and Serum Lipid Levels in a Chinese Population.Biochemical genetics · 2026Article
- Accurate assembly of the olive baboon (Papio anubis) genome using long-read and Hi-C data.GigaScience · 2020Article
- Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis.Scientific reports · 2019Article
- Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance.Journal of medical primatology · 2018Article
- Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China.International journal of clinical and experimental medicine · 2015Article
- Identification of candidate genes encoding an LDL-C QTL in baboons.Journal of lipid research · 2013Article
- Baboons as a model to study genetics and epigenetics of human disease.ILAR journal · 2013Review
- The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance.PloS one · 2013Article
- In transition: primate genomics at a time of rapid change.ILAR journal · 2013Review
- Differential microRNA response to a high-cholesterol, high-fat diet in livers of low and high LDL-C baboons.BMC genomics · 2012Article
- Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.Journal of lipid research · 2012Article
- Modularity in the mammalian dentition: mice and monkeys share a common dental genetic architecture.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Effects of diet on genetic regulation of lipoprotein metabolism in baboons.Atherosclerosis · 2010Article
- Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.).Cardiovascular diabetology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol. In this study, 126 overlapping traits related to both LDL and HDL metabolism were normalized and subjected to genome-wide linkage screening. As was expected, the traits were highly, but not completely, correlated. We exploited the information in these correlated traits by focusing on those genomic regions harboring quantitative trait loci (QTL) for multiple traits, reasoning that the more influential genes would impact a larger number of traits. This study identified five major QTL clusters (each with at least two significant logarithm of the odds scores >4.7), two of which had not been previously reported in baboons. One of these mapped to the baboon ortholog of human chromosome 1p32-p34 and influenced concentrations of LDL-cholesterol on Basal and high-fat, low-cholesterol diets. The other novel QTL cluster mapped to the baboon ortholog of human chromosome 12q13.13-q14.1 and influenced LDL size properties on high-fat, low-cholesterol and high-fat, high-cholesterol, but not Basal, diets. Confirming the value of this approach, three of the QTL clusters replicated published linkage findings for the same or similar traits.
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