ArticleDevelopment (Cambridge, England)2009
Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila.PLoS biology · 2023Article
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- A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development.PLoS biology · 2023Article
- JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos.Nature communications · 2023Article
- Regulation of axon pathfinding by astroglia across genetic model organisms.Frontiers in cellular neuroscience · 2023Review
- The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.Nature communications · 2020Article
- Review
- Article
- I Spy in the Developing Fly a Multitude of Ways to Die.Journal of developmental biology · 2018Review
- A versatile genetic tool to study midline glia function in the Drosophila CNS.Developmental biology · 2017Article
- Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.Journal of cell science · 2016Article
- Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation.Developmental biology · 2012Article
- Worker honeybee brain proteome.Journal of proteome research · 2012Article
- Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration.Developmental biology · 2012Article
- Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ.PloS one · 2012Article
- Morphological characterization of the entire interneuron population reveals principles of neuromere organization in the ventral nerve cord of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Using the Drosophila melanogaster D17-c3 cell culture system to study cell motility.Nature protocols · 2011Article
- Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates.Development (Cambridge, England) · 2011Article
- Comparing peripheral glial cell differentiation in Drosophila and vertebrates.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Glia play crucial roles in ensheathing axons, a process that requires an intricate series of glia-neuron interactions. The membrane-anchored protein Wrapper is present in Drosophila midline glia and is required for ensheathment of commissural axons. By contrast, Neurexin IV is present on the membranes of neurons and commissural axons, and is highly concentrated at their interfaces with midline glia. Analysis of Neurexin IV and wrapper mutant embryos revealed identical defects in glial migration, ensheathment and glial subdivision of the commissures. Mutant and misexpression experiments indicated that Neurexin IV membrane localization is dependent on interactions with Wrapper. Cell culture aggregation assays and biochemical experiments demonstrated the ability of Neurexin IV to promote cell adhesion by binding to Wrapper. These results show that neuronal-expressed Neurexin IV and midline glial-expressed Wrapper act as heterophilic adhesion molecules that mediate multiple cellular events involved in glia-neuron interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.