ArticleApplied and environmental microbiology2009
Influence of a probiotic strain of Enterococcus faecium on Salmonella enterica serovar Typhimurium DT104 infection in a porcine animal infection model.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Feeding of the probiotic bacterium Enterococcus faecium NCIMB 10415 differentially affects shedding of enteric viruses in pigs.Veterinary research · 2012Trial
- Immunorestorative effects of Limosilactobacillus reuteri LR6 in protein-energy malnourished mice under pathogen and allergen challenge.Archives of microbiology · 2026Article
- Effect of Synbiotics on Hygienic Quality of Feed and Pork.Animals : an open access journal from MDPI · 2026Article
- Effect of hydrolyzable tannin and organic acids on productive performance, ileal microbiota and histomorphology, and immunocompetence indices of broiler chicken.Scientific reports · 2025Article
- Antibiotic Alternatives and Next-Generation Therapeutics forAntibiotics (Basel, Switzerland) · 2025Review
- ConcurrentmSphere · 2024Article
- Effects of Probiotic Enterococcus faecium from Yak on the Intestinal Microflora and Metabolomics of Mice with Salmonella Infection.Probiotics and antimicrobial proteins · 2024Article
- Detection of EnterotoxigenicLife (Basel, Switzerland) · 2023Article
- A Simple Assay to AssessMicroorganisms · 2023Article
- Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens.Journal of animal science and biotechnology · 2022Article
- Effects ofVeterinarni medicina · 2022Article
- Efficacy ofAntibiotics (Basel, Switzerland) · 2022Article
- Effects of Milk Replacer-BasedMicrobiology spectrum · 2022Article
- The Game for Three:Frontiers in microbiology · 2022Review
- Intestinal Mucosal Immunity-Mediated Modulation of the Gut Microbiome by Oral Delivery ofFrontiers in immunology · 2022Article
- The Protective Effect ofFrontiers in veterinary science · 2021Article
- Insight into the intestinal microbiome of farrowing sows following the administration of garlic (Allium sativum) extract and probiotic bacteria cultures under farming conditions.BMC veterinary research · 2020Article
- Probiotics-Live Biotherapeutics: a Story of Success, Limitations, and Future Prospects-Not Only for Humans.Probiotics and antimicrobial proteins · 2020Review
- Enterococcus faecium supplementation in sows during gestation and lactation improves the performance of sucking piglets.Veterinary medicine and science · 2020Article
- Development of Salmonellosis as Affected by Bioactive Food Compounds.Microorganisms · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beneficial effects of probiotic Enterococcus spp. in different hosts, such as mice and humans, have previously been reported in several studies. However, studies of large domestic animals, as well as challenge studies with pathogenic microorganisms, are very rare. Here, we investigated the influence of oral treatment of pigs with the probiotic bacterium Enterococcus faecium NCIMB 10415 on Salmonella enterica serovar Typhimurium DT104 infections in weaning piglets. Clinical symptoms, fecal excretion, the organ distribution of Salmonella, and the humoral immune response (immunoglobulin G [IgG], IgM, and IgA levels) in serum were examined. A pool of 89 piglets was randomly divided into probiotic and control groups. The probiotic group received a feed supplement containing E. faecium starting on day 14 postpartum prior to challenge with Salmonella serovar Typhimurium DT104 at 28 days postpartum. After challenge with Salmonella serovar Typhimurium DT104, piglets in both groups showed no severe clinical signs of salmonellosis. However, fecal excretion and colonization of Salmonella in organs were significantly greater in piglets fed E. faecium. Likewise, the humoral immune response against Salmonella (serum IgM and IgA levels) was significantly greater in the probiotic group animals than in control animals. The results of this study suggest that E. faecium NCIMB 10415 treatment enhanced the course of infection in weaning piglets challenged with Salmonella serovar Typhimurium DT104. However, the probiotic treatment also appeared to result in greater production of specific antibodies against Salmonella serovar Typhimurium DT104.
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