ArticleApplied and environmental microbiology2009
Identification and characterization of the phage gene sav, involved in sensitivity to the lactococcal abortive infection mechanism AbiV.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Revisiting lactococcal abortive infection-like antiphage systems: diversity, structures, and mechanisms.FEMS microbiology reviews · 2026Review
- In silico approaches for discovering microbial antiviral defense systems.Briefings in bioinformatics · 2025Review
- The great phage escape: Activating and escaping lactococcal antiphage systems.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Potential of training of anti-mSystems · 2024Article
- Bacteriophage strategies for overcoming host antiviral immunity.Frontiers in microbiology · 2023Review
- Genome Characterization of Nocturne116, NovelMicroorganisms · 2021Article
- Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages.Scientific reports · 2016Article
- Mutational Analysis of the Antitoxin in the Lactococcal Type III Toxin-Antitoxin System AbiQ.Applied and environmental microbiology · 2015Article
- Methyltransferases acquired by lactococcal 936-type phage provide protection against restriction endonuclease activity.BMC genomics · 2014Article
- Progress in lactic acid bacterial phage research.Microbial cell factories · 2014Review
- SP10 infectivity is aborted after bacteriophage SP10 infection induces nonA transcription on the prophage SPβ region of the Bacillus subtilis genome.Journal of bacteriology · 2014Article
- Revenge of the phages: defeating bacterial defences.Nature reviews. Microbiology · 2013Review
- Effect of the abortive infection mechanism and type III toxin/antitoxin system AbiQ on the lytic cycle of Lactococcus lactis phages.Journal of bacteriology · 2013Article
- Involvement of the major capsid protein and two early-expressed phage genes in the activity of the lactococcal abortive infection mechanism AbiT.Applied and environmental microbiology · 2012Article
- Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.PLoS genetics · 2012Article
- Bacteriophages of lactic acid bacteria and their impact on milk fermentations.Microbial cell factories · 2011Review
- Lactococcal abortive infection protein AbiV interacts directly with the phage protein SaV and prevents translation of phage proteins.Applied and environmental microbiology · 2010Article
- Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia.Journal of bacteriology · 2009Article
- Activation and transfer of the chromosomal phage resistance mechanism AbiV in Lactococcus lactis.Applied and environmental microbiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactococcus lactis phage mutants that are insensitive to the recently characterized abortive infection mechanism AbiV were isolated and analyzed in an effort to elucidate factors involved in the sensitivity to AbiV. Whole-genome sequencing of the phage mutants p2.1 and p2.2 revealed mutations in an orf that is transcribed early, indicating that this orf was responsible for AbiV sensitivity. Sequencing of the homologous regions in the genomes of other AbiV-insensitive mutants derived from p2 and six other lactococcal wild-type phages revealed point mutations in the homologous orf sequences. The orf was named sav (for sensitivity to AbiV), and the encoded polypeptide was named SaV. The purification of a His-tagged SaV polypeptide by gel filtration suggested that the polypeptide formed a dimer in its native form. The overexpression of SaV in L. lactis and Escherichia coli led to a rapid toxic effect. Conserved, evolutionarily related regions in SaV polypeptides of different phage groups are likely to be responsible for the AbiV-sensitive phenotype and the toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.