ArticleJournal of bacteriology2009
vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- A protease-sensing circuit links neutrophil inflammation to virulence regulation inbioRxiv : the preprint server for biology · 2026Article
- Signaling Peptide SpoV Is Essential forMicroorganisms · 2021Article
- TheJournal of bacteriology · 2021Article
- Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme.Molecular microbiology · 2015Article
- Quorum sensing in group A Streptococcus.Frontiers in cellular and infection microbiology · 2014Review
- Staphylococcus aureus α-hemolysin promotes platelet-neutrophil aggregate formation.The Journal of infectious diseases · 2013Article
- Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.Infection and immunity · 2013Article
- Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal.Molecular microbiology · 2012Article
- An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.Molecular microbiology · 2011Article
- CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.Infection and immunity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.