ArticleJournal of bacteriology2009
Genetic variation and evolution of the pathogenicity island of Enterococcus faecalis.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Phylogenetic and pathogenic description of Enterococcus faecalis at a Northern Chinese hospital.BMC microbiology · 2025Article
- Unveiling the probiotic potential of Enterococcus spp.: Mechanisms and roles in animal and human health, A comprehensive review.World journal of microbiology & biotechnology · 2025Review
- Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025Review
- Molecular identification and probiotic potential characterization of lactic acid bacteria isolated from the pigs with superior immune responses.Frontiers in microbiology · 2024Article
- Virulence-related genotypic differences amongFrontiers in cellular and infection microbiology · 2023Article
- Let Me Upgrade You: Impact of Mobile Genetic Elements on Enterococcal Adaptation and Evolution.Journal of bacteriology · 2021Review
- The Many Faces ofMicroorganisms · 2021Review
- Antimicrobial Resistance and Virulence Factor Gene Profiles ofJournal of veterinary research · 2021Article
- Purification and characterization of bacteriocins-like inhibitory substances from food isolated Enterococcus faecalis OS13 with activity against nosocomial enterococci.Scientific reports · 2021Article
- Enterococci from Wild Magellanic Penguins (Spheniscus magellanicus) as an Indicator of Marine Ecosystem Health and Human Impact.Applied and environmental microbiology · 2020Article
- Application of median lethal concentration (LCBMC research notes · 2020Article
- Deciphering the role of insertion sequences in the evolution of bacterial epidemic pathogens withMicrobial genomics · 2020Article
- Chicken Meat-Associated Enterococci: Influence of Agricultural Antibiotic Use and Connection to the Clinic.Applied and environmental microbiology · 2019Article
- Biofilm formation capacity and presence of virulence factors among commensal Enterococcus spp. from wild birds.Scientific reports · 2019Article
- Pathogenicity of Enterococci.Microbiology spectrum · 2019Review
- Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream.Science translational medicine · 2019Article
- The Enterococcus: a Model of Adaptability to Its Environment.Clinical microbiology reviews · 2019Review
- Enterococcal Genetics.Microbiology spectrum · 2019Review
- Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Enterococcus faecalis is a leading cause of nosocomial infections and is known for its ability to acquire and transfer virulence and antibiotic resistance determinants from other organisms. A 150-kb pathogenicity island (PAI) encoding several genes that contribute to pathogenesis was identified among antibiotic-resistant clinical isolates. In the current study, we examined the structure of the PAI in a collection of isolates from diverse sources in order to gain insight into its genesis and dynamics. Using multilocus sequence typing to assess relatedness at the level of strain background and microarray analysis to identify variations in the PAI, we determined the extent to which structural variations occur within the PAI and also the extent to which these variations occur independently of the chromosome. Our findings provide evidence for a modular gain of defined gene clusters by the PAI. These results support horizontal transfer as the mechanism for accretion of genes into the PAI and highlight a likely role for mobile elements in the evolution of the E. faecalis PAI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.