ArticleThe Journal of biological chemistry2009
Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spines.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
- Geometry effects on protein mobility in a synapse.Biophysical journal · 2025Article
- The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity.Frontiers in synaptic neuroscience · 2022Review
- Altering integrin engagement regulates membrane localization of KJournal of cell science · 2019Article
- Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphologyThe Journal of biological chemistry · 2019Article
- Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction.Neuron · 2018Article
- Linking Nanoscale Dynamics of AMPA Receptor Organization to Plasticity of Excitatory Synapses and Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Dynamic imaging of AMPA receptor trafficking in vitro and in vivo.Current opinion in neurobiology · 2017Review
- Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density.Cell reports · 2015Article
- The organization of AMPA receptor subunits at the postsynaptic membrane.Hippocampus · 2015Article
- GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.Biochimica et biophysica acta · 2015Article
- TIRFM and pH-sensitive GFP-probes to evaluate neurotransmitter vesicle dynamics in SH-SY5Y neuroblastoma cells: cell imaging and data analysis.Journal of visualized experiments : JoVE · 2015Article
- Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.The Journal of biological chemistry · 2014Article
- Residence times of receptors in dendritic spines analyzed by stochastic simulations in empirical domains.Biophysical journal · 2014Article
- The dendritic SNARE fusion machinery involved in AMPARs insertion during long-term potentiation.Frontiers in cellular neuroscience · 2014Review
- Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.The Journal of general physiology · 2014Article
- The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
- How to scale down postsynaptic strength.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling.Traffic (Copenhagen, Denmark) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The surface expression and localization of AMPA receptors (AMPARs) at dendritic spines are tightly controlled to regulate synaptic transmission. Here we show that de novo exocytosis of the GluR2 AMPAR subunit occurs at the dendritic shaft and that new AMPARs diffuse into spines by lateral diffusion in the membrane. However, membrane topology restricts this lateral diffusion. We therefore investigated which mechanisms recruit AMPARs to spines from the shaft and demonstrated that inhibition of dynamin GTPase activity reduced lateral diffusion of membrane-anchored green fluorescent protein and super-ecliptic pHluorin (SEP)-GluR2 into spines. In addition, the activation of synaptic N-methyl-d-aspartate (NMDA) receptors enhanced lateral diffusion of SEP-GluR2 and increased the number of endogenous AMPARs in spines. The NMDA-invoked effects were prevented by dynamin inhibition, suggesting that activity-dependent dynamin-mediated endocytosis within spines generates a net inward membrane drift that overrides lateral diffusion barriers to enhance membrane protein delivery into spines. These results provide a novel mechanistic explanation of how AMPARs and other membrane proteins are recruited to spines by synaptic activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.