ReviewCurrent opinion in chemical biology2009
Control of radical chemistry in the AdoMet radical enzymes.
Review in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 72 citations in OpenAlex.
- The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase, or Epimerase upon Mutation of a Single Active Site Serine Residue.Journal of the American Chemical Society · 2026Article
- Initiation, Propagation, and Termination in the Chemistry of Radical SAM Enzymes.Biochemistry · 2024Review
- Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch RadicalJournal of the American Chemical Society · 2022Article
- HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue.Journal of the American Chemical Society · 2021Article
- Computational Approaches: An Underutilized Tool in the Quest to Elucidate Radical SAM Dynamics.Molecules (Basel, Switzerland) · 2021Review
- Mechanistic Investigation of 1,2-Diol Dehydration of Paromamine Catalyzed by the RadicalJournal of the American Chemical Society · 2021Article
- Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes.The Journal of biological chemistry · 2020Article
- Radical SAM enzymes: surprises along the path to understanding mechanism.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Review
- Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants.Methods in enzymology · 2017Article
- Advanced paramagnetic resonance spectroscopies of iron-sulfur proteins: Electron nuclear double resonance (ENDOR) and electron spin echo envelope modulation (ESEEM).Biochimica et biophysica acta · 2015Review
- Mechanistic Enzymology of the Radical SAM Enzyme DesII.Israel journal of chemistry · 2015Article
- Mechanistic studies of the radical S-adenosylmethionine enzyme DesII with TDP-D-fucose.Angewandte Chemie (International ed. in English) · 2015Article
- Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange.FEBS letters · 2014Article
- Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.Nature chemical biology · 2014Article
- Iron(IV)hydroxide pK(a) and the role of thiolate ligation in C-H bond activation by cytochrome P450.Science (New York, N.Y.) · 2013Article
- Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine.Current opinion in chemical biology · 2013Review
- 4-Hydroxyphenylacetate decarboxylase activating enzyme catalyses a classical S-adenosylmethionine reductive cleavage reaction.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.Nature chemical biology · 2013Article
- EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Emerging themes in radical SAM chemistry.Current opinion in structural biology · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the reactivity between the iron-sulfur cluster and AdoMet, and controlling the subsequent radical transformations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.