Evidence map›Paper›PMID 19269850›Full record

ReviewSeminars in immunology2009

CD4 memory T cells: what are they and what can they do?

Megan K L MacLeod, Eric T Clambey, John W Kappler, Philippa Marrack

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. A comprehensive overview of monkeypox virus disease.Tropical medicine and health · 2026
    Review
  4. Article
  5. Research square · 2026
    Article
  6. Characterization of Th2 Serum Immune Response in Acute Appendicitis.International journal of molecular sciences · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. A Bioinformatic Assay of Quercetin in Gastric Cancer.International journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Megan K L MacLeodHoward Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. macleodm@njc.org
Eric T Clambey
John W Kappler
Philippa Marrack

Funding

THE REGULATION OF V ALPHA 7 EXPRESSING T CELLSP01AI022295 · NIAID · NATIONAL JEWISH HEALTH · PI REFAELI, YOSEF · 1985 to 2011
$11.7M
CHARACTERISTICS OF T CELL RECEPTORSR01AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 1985 to 2022
$7.3M
Control of Chemokine Production by Memory T CellsR01AI052225 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 2002 to 2006
$1.3M
CHARACTERISTICS OF T-CELL RECEPTORSR37AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 1992 to 2001
$522k
Characteristics of T Cell ReceptorsR56AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 2012 to 2012
$410k
Howard Hughes Medical InstituteNIAID NIH HHS AI-18785NIAID NIH HHS AI-22295NIAID NIH HHS AI-52225NIAID NIH HHS P01 AI022295NIAID NIH HHS R01 AI018785NIAID NIH HHS R01 AI052225NIAID NIH HHS R37 AI018785NIAID NIH HHS R56 AI018785
6 · The paper itself

Abstract

Immunological memory provides the basis for successful vaccines. It is important to understand the properties of memory cells. There is much known about the phenotype and functions of memory CD8 T cells, less about memory B cells, while CD4 memory T cells have proved difficult to study. Differences in the types of memory CD4 cells studied and the difficulties of tracking the small number of cells have led to conflicting and unclear results. Here we discuss the different systems used to study CD4 memory cells and ask whether, and in what circumstances, memory CD4 cells could provide protection against infections.

Indexed as

Immunologic MemoryAnimalsB-LymphocytesCD4-Positive T-LymphocytesCell CommunicationCytokinesCytotoxicity, ImmunologicEpitopesHumansImmunoglobulin Class SwitchingInfection ControlInfectionsLymphocyte ActivationT-Lymphocyte SubsetsVaccinationVaccinesCytokinesEpitopesVaccines

Identifiers

PMID19269850
PMCPMC2679806

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.