ReviewCurrent opinion in immunology2009
Untangling the T branch of the hematopoiesis tree.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes.Genome research · 2024Article
- Mechanisms Underlying the Development of Murine T-Cell Lymphoblastic Lymphoma/Leukemia Induced by Total-Body Irradiation.Cancers · 2024Review
- Leaving no one behind: tracing every human thymocyte by single-cell RNA-sequencing.Seminars in immunopathology · 2021Review
- DN2 Thymocytes Activate a Specific Robust DNA Damage Response to Ionizing Radiation-Induced DNA Double-Strand Breaks.Frontiers in immunology · 2018Article
- Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations.Cell cycle (Georgetown, Tex.) · 2013Article
- Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.Seminars in immunology · 2011Review
- The Paf oncogene is essential for hematopoietic stem cell function and development.The Journal of experimental medicine · 2011Article
- Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion.International immunopharmacology · 2011Review
- The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity.Molecular immunology · 2011Review
- Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissue.Clinical and experimental immunology · 2011Review
- Multilayered specification of the T-cell lineage fate.Immunological reviews · 2010Review
- Eliciting the T cell fate with Notch.Seminars in immunology · 2010Review
- Decision checkpoints in the thymus.Nature immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
T cells develop in the thymus. Previous work suggested an early separation of lymphoid from myeloerythroid lineages during hematopoiesis and hypothesized the thymus was settled exclusively by lymphoid-restricted hematopoietic progenitors. Recent data have instead established the existence of lymphoid-myeloid progenitors, which possess lymphoid and myeloid lineage potentials but lack erythroid potential. Myeloid and lymphoid potentials are present at the clonal level in early thymic progenitors, confirming that progenitors settling the thymus include lymphoid-myeloid progenitors. These results revise our view of the T lineage branch of hematopoiesis and focus attention on the generation, circulation, and homing of lymphoid-myeloid progenitors to the thymus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.