ArticleCurrent opinion in immunology2009
Multiple regulatory and effector roles of autophagy in immunity.
Article in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 99 citations in OpenAlex.
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- Cell death pathways and viruses: Role of microRNAs.Molecular therapy. Nucleic acids · 2021Review
- Protective role of fermented mulberry leave extract in LPS‑induced inflammation and autophagy of RAW264.7 macrophage cells.Molecular medicine reports · 2020Article
- Effect and underlying mechanisms of airborne particulate matter 2.5 (PM2.5) on cultured human corneal epithelial cells.Scientific reports · 2020Article
- "Repair Me if You Can": Membrane Damage, Response, and Control from the Viral Perspective.Cells · 2020Review
- Physiological and pathological regulation of autophagy in pregnancy.Archives of gynecology and obstetrics · 2020Review
- ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.International journal of oncology · 2020Article
- Quantitative Proteomic Analysis Uncovers the Mediation of Endoplasmic Reticulum Stress-Induced Autophagy in DHAV-1-Infected DEF Cells.International journal of molecular sciences · 2019Article
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- Review
- The Immune Escape Mechanisms ofInternational journal of molecular sciences · 2019Review
- Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.Arthritis research & therapy · 2018Article
- miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6.Archives of virology · 2017Article
- Article
- Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model.Autophagy · 2014Article
- Autophagy is redundant for the host defense against systemic Candida albicans infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.PloS one · 2014Article
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Abstract
Autophagy is a cytoplasmic homeostasis pathway, enabling cells to digest their own cytosol, remove toxic protein aggregates, and eliminate defective or surplus organelles. A plenitude of studies has now expanded roles of autophagy to both effector and regulatory functions in innate and adaptive immunity. In its role of an immunological effector, autophagy plays many parts: (i) In its most primeval manifestation, it captures and digests intracellular microbes, (ii) it is an antimicrobial output of Toll-like receptor (TLR) response to pathogen associated molecular patterns (PAMP), and (iii) it is an effector of Th1-Th2 polarization in resistance or susceptibility to intracellular pathogens. As a regulator of immunity, autophagy plays a multitude of functions: (i) It acts as a topological inversion device servicing both innate and adaptive immunity by delivering cytosolic antigens to the lumen of MHC II compartments and cytosolic PAMPs to endosomal TLRs, (ii) it is crucial in T cell repertoire selection in the thymus and control of central tolerance, (iii) it plays a role in T and B cell homeostasis, and (iv) it is of significance for inflammatory pathology. A properly functioning autophagy helps prevent autoimmunity and assists in clearing pathogens. When aberrant, it contributes to human inflammatory disorders such as Crohn's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.