Evidence map›Paper›PMID 19268688›Full record

ReviewPharmacology & therapeutics2009

The dynamic effects of nicotine on the developing brain.

Jennifer B Dwyer, Susan C McQuown, Frances M Leslie

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
306citing papers in PubMed, 7 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

306 citing papers in PubMed, 7 syntheses or guidelines pooled it, 562 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Willingness to Use Commercial Nicotine Gums, Lozenges, and Gummies Among Nontobacco Using Adolescents in Southern California.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023
    Trial
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  13. Review
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246 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jennifer B DwyerDepartment of Pharmacology, Med Surge II, School of Medicine, University of California, Irvine, CA 92697, USA. jbdwyer@uci.edu
Susan C McQuown
Frances M Leslie
University of California, Irvine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
NICOTINE REGULATION OF DEVELOPING BRAIN CATECHOLAMINESR01DA010612 · NIDA · UNIVERSITY OF CALIFORNIA IRVINE · PI LESLIE, FRANCES M. · 1997 to 2005
$1.9M
Mechanisms of Adolescent Vulnerability to Drugs of AbuseR01DA019138 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LESLIE, FRANCES M. · 2004 to 2008
$1.3M
NIDA NIH HHS DA 10612NIDA NIH HHS DA 19138NIDA NIH HHS R01 DA010612NIDA NIH HHS R01 DA019138NIGMS NIH HHS GM 08620NIGMS NIH HHS T32 GM008620
6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation during the prenatal, early postnatal, and adolescent periods. During these developmental windows, nAChRs are often transiently upregulated or change subunit composition in those neural structures that are undergoing major phases of differentiation and synaptogenesis, and are sensitive to environmental stimuli. Nicotine exposure, most often via tobacco smoke, but increasingly via nicotine replacement therapy, has been shown to have unique effects on the developing human brain. Consistent with a dynamic developmental role for acetylcholine, exogenous nicotine produces effects that are unique to the period of exposure and that impact the developing structures regulated by acetylcholine at that time. Here we present a review of the evidence, available from both the clinical literature and preclinical animal models, which suggests that the diverse effects of nicotine exposure are best evaluated in the context of regional and temporal expression patterns of nAChRs during sensitive maturational periods, and disruption of the normal developmental influences of acetylcholine. We present evidence that nicotine interferes with catecholamine and brainstem autonomic nuclei development during the prenatal period of the rodent (equivalent to first and second trimester of the human), alters the neocortex, hippocampus, and cerebellum during the early postnatal period (third trimester of the human), and influences limbic system and late monoamine maturation during adolescence.

Indexed as

AdolescentAnimalsBrainFetal DevelopmentHumansInfantInfant, NewbornNicotineRatsReceptors, NicotinicNicotineReceptors, Nicotinic

Identifiers

PMID19268688
PMCPMC2746456
OpenAlexW2072987235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.